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Tg(KRT5-cre/ERT)SCmch - Hemolymphoid System
Recombinase Activity Detail
Allele Information
transgene insertion S, Chun-Ming Chen
Driver: KRT5
Type: Transgenic (Recombinase)
Synonym: spontaneous BK5-CreERT transgene, Tg(BK5-CreERT)S
Molecular description: This transgene comprises 5.2 kb of 5' flanking and promoter DNA from the bovine keratin 5 gene and a rabbit beta-globin intron followed by the Cre recombinase coding sequence joined in-frame to a mutated estrogen receptor ligand binding domain (ERT), then by an SV40 poly(A) signal and two reversed copies of the ~1.2 kb HS4 5' insulator sequence from the chicken beta-globin gene. Double transgenic mice for cre and the R26-LacZ reporter demonstrate constitive expression (in absence of 4-hydroxy tamoxifen treatment) from about E14.5 in most keratin 5 expressing tissues; the thymic epithelium and the Mullerian vagina show significant expression only after postnatal day 7. Additionally, only this line (in contrast with Tg(KRT5-Cre/ERT)ICmch) exhibits Cre recombinase activity in KRT5-expressing epithelial cells of the mammary gland.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(KRT5-cre/ERT)SCmch activity also observed in:
alimentary system, integumental system, renal and urinary system, reproductive system, respiratory system, sensory organs
Tissue Information
Hemolymphoid System Other recombinase alleles with activity in Hemolymphoid System tissues:
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J:143780 Fig. 3
Recombinase Activity
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Assays Genotypic Background Result Notes  
All for this allele: 2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory