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Tg(KRT5-cre/ERT)ICmch - Renal & Urinary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(KRT5-cre/ERT)ICmch
transgene insertion I, Chun-Ming Chen 		Driver: KRT5
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: K5-CreER, Tg(BK5-CreERT)I
Molecular description: This transgene comprises 5.2 kb of 5' flanking and promoter DNA from the bovine keratin 5 gene and a rabbit beta-globin intron followed by the Cre recombinase coding sequence joined in-frame to a mutated estrogen receptor ligand-binding domain (ERT) that recognizes 4-hydroxytamoxifen (4-OHT), but not endogenous estrogen (beta-17 estradiol), then by an SV40 poly(A) signal and two reversed copies of the ~1.2 kb HS4 5' insulator sequence from the chicken beta-globin gene. X-gal staining of tissues from 4-OHT treated mice from crosses of females with the transgene and males bearing the Cre reporter, Gt(ROSA)26Sor, demonstrated expression in all tissues expressing keratin 5 -- generally, in stratified and pseudo-stratified epithelia throughout the body.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(KRT5-cre/ERT)ICmch activity also observed in:
alimentary system, hemolymphoid system, integumental system, reproductive system
Tissue Information
Renal & Urinary System Other recombinase alleles with activity in Renal & Urinary System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory