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Allele Information
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Allele:
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Mcm2tm1(cre/ERT2)Scpr
minichromosome maintenance complex component 2;
targeted mutation 1, Steven C Pruitt
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Driver: Mcm2
Type: Targeted
(Inducible, Recombinase)
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Inducer:
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tamoxifen
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Synonym:
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Mcm2IRES-CreERT2, Mcm2tm1(cre)Scpr
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Molecular description:
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An IRES element, a cre/ESRI fusion gene. and a PGK-neo selection cassette were inserted into exon 16 3' to the stop codon. A cryptic polyA site 3' of the stop codon was deleted in order to permit cre expression. Cre expression was confirmed by EGFP expression after tamoxifen treatment of mice also carrying the Tg(CAG-Bgeo/GFP)21Lbe transgene. MCM2 expression was reduced to 62% of normal in heterozygotes and 35% in homozygotes.
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Find mice (IMSR):
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Mouse Strains:
1
strain available
Cell Lines:
0 lines available
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Additional Tissues:
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Mcm2tm1(cre/ERT2)Scpr activity also observed in:
alimentary system,
cardiovascular system,
head,
integumental system,
nervous system,
skeletal system
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Tissue Information
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Hemolymphoid System
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Other recombinase alleles with activity in Hemolymphoid System tissues:
Abcg2tm1.1(cre/Esr1*)Jvbe,
Agrptm1(cre)Lowl,
Airetm3(cre)Mmat,
Aldh1l1em1(cre/ERT2)Nju,
Alpltm1(cre)Nagy,
Amhr2em1(icre)Fjd,
Aplnrem3(cre/ERT2)Smoc,
Bhlhe41em1(cre)Cya,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Cd19tm1(cre)Cgn,
Cd209btm1.1(cre,HBEGF)Bcgen,
Cd34tm1.1(cre/ERT2)Lizg,
Cd40lgtm1.1(cre)Tega,
Clec11aem3(cre/ERT2)Sjm,
Clec9atm2.1(icre)Crs,
Clutm2(EGFP/cre/ERT2)Wtsi,
Col2a1em2(dre)Smoc,
Commd10Tg(Vav1-icre)A2Kio,
Crhtm1(cre)Zjh,
Crybb1em1(icre)Cln,
Cx3cr1tm1.1(cre)Jung,
Cx3cr1tm2.1(cre/ERT2)Jung,
Cx3cr1tm2.1(cre/ERT2)Litt,
Cxcr4tm1.1(cre/ERT2)Stum,
Cxcr5em1(cre/ERT2)Yhar,
Ddx4em1(cre/ERT2)Utr,
Dmp1tm1(cre)Msue,
Dnttem2(icre)Trx,
Dpttm1.1(cre/ERT2)Snjt,
E2f1Tg(Wnt1-cre)2Sor,
Emx1tm1(cre)Krj,
Eporem1(cre)Bcgen,
Eportm1.1(EGFP/icre)Uk,
Epxtm1.1(cre)Jlee,
Fgf16tm1.1(cre)Sms,
Fgf18tm2.2(cre/ERT2)Dor,
Flt4tm2.1(cre/ERT2)Sgo,
Flt4tm2.1(cre/Esr1*)Ichi,
Foxa2tm2.1(cre/Esr1*)Moon,
Foxd1tm1(GFP/cre)Amc,
Foxn1tm3(cre)Nrm,
Foxp3tm4(YFP/icre)Ayr,
Gad2tm2(cre)Zjh,
Gas1em1(icre/ERT2)Nono,
Gfi1tm1(cre)Gan,
Gja10tm2.1(cre)Kwi,
Glp1rtm1.1(cre)Cors,
Gnao1tm2(EGFP/cre/ERT2)Wtsi,
Golm1tm2(EGFP/cre/ERT2)Wtsi,
Grem1tm1.1(cre/ERT2)Snjt,
Gt(ROSA)26Sorem1(CAG-Ncre/vvd*,-vvd*/Ccre)Larc,
Gt(ROSA)26Sortm1.1(CAG-cre)Jphe,
Gt(ROSA)26Sortm1(cre/ERT2)Tyj,
Gt(ROSA)26Sortm2(icre/ERT2)Jphe,
Gt(ROSA)26Sortm5(dre)Dwi,
Gt(ROSA)26Sortm6(dre/PGR*)Dwi,
Gt(ROSA)26Sortm8(CAG-dre/ERT2)Bzsh,
H2az2Tg(Wnt1-cre)11Rth,
Hlfem1(cre/ERT2)Smoc,
Hoxa11em1(cre/ERT2)Dmwe,
Hprt1tm1(CAG-cre)Mnn,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Ifi208Tg(Cspg4-cre)1Akik,
Ighg1tm1(cre)Cgn,
Ihhem1(Tomm20/mKate2,dre)Xya,
Islrtm1.1(HBEGF,cre)Mat,
Islrtm2.1(cre/ERT2)Mat,
Itga8tm1.1(cre/ERT2)Jomm,
Kittm1.1(cre)Jmol,
Kittm1(cre/ERT2)Dsa,
Kittm2.1(cre/Esr1*)Jmol,
Klrg1tm1.1(EGFP/icre)Flv,
Krt17tm1(cre)Murr,
Leprtm2(cre)Rck,
Ltftm1(icre)Tdku,
Ly6atm1.1(cre/ERT2)Geno,
Ly6atm2.1(cre/Esr1*)Jmol,
Ly6gtm2621(cre)Arte,
Lyve1tm1.1(EGFP/cre)Cys,
Lyz2tm1(cre)Ifo,
Mcpt8tm1.1(cre)Ics,
Mecomtm4.1(cre/ERT2)Aspe,
Mki67tm1.1(cre/ERT2)Bsed,
Mnx1tm4(cre)Tmj,
Myf5tm3(cre)Sor,
Myh6em2(cre)Smoc,
Ndor1Tg(UBC-cre/ERT2)1Ejb,
Neurod6tm1(cre)Kan,
Nkx2-5tm1(cre)Rjs,
Notch1tm3(cre)Rko,
Osr2tm2(cre)Jian,
P2ry12em1(icre/ERT2)Tda,
Pax3tm1(cre)Joe,
Pdgfratm1.1(EGFP/cre/ERT2)Hyma,
Pgrtm2(cre)Lyd,
Piezo1em2(cre/ERT2)Smoc,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Prlrtm1.1(cre)Uboe,
Prtn3tm1.1(cre/ERT2,CD4*)Wkas,
Psmb11tm1.1(icre)Yout,
Pvalbtm1(cre)Arbr,
Rorbtm1.1(cre)Hze,
Rorcem1.1(cre/ERT2)Ayr,
Runx1tm1(cre/Esr1*)Ims,
Runx1tm2.1(cre/Esr1*)Ims,
Shhtm1(EGFP/cre)Cjt,
Siglechtm1.1(icre)Ciphe,
Slc17a6tm2(cre)Lowl,
Slc6a3tm1.1(cre)Bkmn,
Sox17tm1(icre)Heli,
Sox17tm2.1(icre)Heli,
Sox17tm4.1(icre/ERT2)Heli,
Sptbtm2(EGFP/cre/ERT2)Wtsi,
Ssttm2.1(cre)Zjh,
Taglntm2(cre)Yec,
Tas2r131tm2.1(cre)Uboe,
Tbx21tm1.1(cre/ERT2)Ayr,
Tbx21tm2.1(cre)Ayr,
Tekem1(dre)Bzsh,
Tektm1.1(icre/Esr1*)Hrr,
Tg(Acp5-cre)3Rda,
Tg(Acp5-cre)4Rda,
Tg(ACTA1-cre)79Jme,
Tg(ACTB-cre)1Tes,
Tg(Aicda-cre)9Mbu,
Tg(Aicda-cre,-CD2)1Hon,
Tg(Aicda-cre,-CD2)dME1Hon,
Tg(Aire-cre)1Mnt,
Tg(Aire-cre)410-5Mmat,
Tg(Aire-cre/ERT2*)1Mand,
Tg(Amh-cre)8815Reb,
Tg(CAG-cre/Esr1*)5Amc,
Tg(Ccr2-cre)584Hohl,
Tg(CD2-icre)4Kio,
Tg(Cd4-cre)1Cwi,
Tg(Cdh16-cre)91Igr,
Tg(Cdh5-cre)1Nmoc,
Tg(Cdh5-cre)1Spe,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(CDX2-cre)101Erf,
Tg(Chst4-cre)1Hkwa,
Tg(Cldn11-cre/ERT2)151Tmak,
Tg(CMA1-cre)6Thhe,
Tg(CMV-cre)1Cgn,
Tg(CMV-cre)1Nagy,
Tg(Col1a2-cre)23Angl,
Tg(Cr2-cre)3Cgn,
Tg(Csf1r-icre)1Jwp,
Tg(Cspg4-cre/Esr1*)BAkik,
Tg(Ctgf-cre)2Aibs,
Tg(Cxcl12-icre/ERT2)L289Nono,
Tg(Cxcl13-cre,-tdTomato)719Biat,
Tg(Cyp17a1-icre)AJako,
Tg(Cyp39a1-cre)1Aibs,
Tg(Ddx4-cre)1Dcas,
Tg(EIIa-cre)C5379Lmgd,
Tg(Eno2-cre)39Jme,
Tg(Epo-cre)44Mym,
Tg(Epx-EYFP/cre)#Voeh,
Tg(Etv2-cre)#Blk,
Tg(Fabp4-cre)1Rev,
Tg(Fcer2a-cre)5Mbu,
Tg(Fgfr3-icre/ERT2)4-2Wdr,
Tg(Flt3-cre)#Ccb,
Tg(Flt3-cre/ERT2)#Ccb,
Tg(Gata1-cre)1Sho,
Tg(Gata1-cre/ERT2)1Mym,
Tg(Gata1-cre/ERT2)2Mym,
Tg(Gata1-cre/ERT2)L245Jeng,
Tg(Gata1-cre/ERT2)L259Jeng,
Tg(Gata1-icre)1Jtp,
Tg(Gata4*G2-cre)#Roja,
Tg(GFAP-cre)25Mes,
Tg(Gfap-cre)73.12Mvs,
Tg(Gfap-cre)77.6Mvs,
Tg(Grik4-cre)G32-4Stl,
Tg(GZMB-cre)1Jcb,
Tg(H2-Ead-cre)158Jcb,
Tg(HBB-cre)12Kpe,
Tg(HBB-cre)27038Kpe,
Tg(HBB-cre)27053Kpe,
Tg(Hoxb7-cre)13Amc,
Tg(Hspa2-cre)1Eddy,
Tg(Il7-cre)CRche,
Tg(Itga2b-cre)AParl,
Tg(Itga2b-cre)NE1/21Emam,
Tg(ITGAM-cre)2781Gkl,
Tg(Itgax-cre)1-1Reiz,
Tg(Kdr-cre)15962Brei,
Tg(KRT14-cre)1Amc,
Tg(KRT14-cre)1Cgn,
Tg(KRT14-cre)8Brn,
Tg(KRT5-cre/ERT)ICmch,
Tg(KRT5-cre/ERT)SCmch,
Tg(Krt8-cre/ERT2,-GFP)1Xin,
Tg(Lck-cre)1Cwi,
Tg(Lck-cre)548Jxm,
Tg(Lck-icre)3779Nik,
Tg(Lepr-cre/ERT2)#Cya,
Tg(Lepr-cre/ERT2)#Rha,
Tg(LPAR4-cre/ERT2,-EGFP)#Hjcho,
Tg(LTF-EGFP/cre/PGR)15Klin,
Tg(Lyve1-cre/ERT2)49Rtem,
Tg(Mafg-Nrf2/cre,-EGFP)737Hozu,
Tg(Mcpt8-icre/ERT2)#Hkar,
Tg(MMTV-cre)1Mam,
Tg(MMTV-cre)4Mam,
Tg(Mx1-cre)1Cgn,
Tg(Mx1-cre)29-4Her,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Myh11-icre/ERT2)1Soff,
Tg(Myh6-cre)2182Mds,
Tg(Ncr1-cre/EGFP)#Cajv,
Tg(Ncr1-cre/ERT2)#Lll,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Nes-cre/ERT2)1Adra,
Tg(Neurog3-cre)C1Able,
Tg(Nmur1-icre,-EGFP)1Dart,
Tg(Nr5a1-cre)2Klp,
Tg(Nr5a1-cre)2Lowl,
Tg(Nrp2-cre,-EGFP)#Qsch,
Tg(Pcp2-cre)1Amc,
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut,
Tg(Pdgfrb-cre/ERT2)6096Rha,
Tg(PDPN-cre)#Rkl,
Tg(Pdzk1ip1-cre/ERT2)#Reiz,
Tg(Pf4-icre)Q3Rsko,
Tg(Plp1-cre/ERT)3Pop,
Tg(Prdm1-cre)1Masu,
Tg(Prox1-cre/ERT2)1Tmak,
Tg(Prrx1-cre)1Cjt,
Tg(Ptprc-cre)#Mez,
Tg(Relb-cre)53Rie,
Tg(Retnla-cre)#Voeh,
Tg(Rorc-cre)1Litt,
Tg(Runx1/Hspa1a-cre/ERT2)3-17Itoy,
Tg(Runx1/Hspa1a-cre/ERT2)5-2Itoy,
Tg(S100a4-cre)1Egn,
Tg(S100a4-flpo)3Lba,
Tg(Scnn1a-cre)3Aibs,
Tg(Sim1-cre)1Lowl,
Tg(Sox10-cre)1Wdr,
Tg(Stra8-icre)1Reb,
Tg(Tagln-cre)1Her,
Tg(Tas2r143-cre/ERT2)#Soff,
Tg(Tek-cre)12Flv,
Tg(Tek-cre)1Arnd,
Tg(Tek-cre)1Ywa,
Tg(Tek-cre)2352Rwng,
Tg(Tek-cre)5326Sato,
Tg(Tek-cre/ERT2)1Arnd,
Tg(Tek-icre/ERT2)1Soff,
Tg(tetO-cre)1Jaw,
Tg(Thy1-cre)1Vln,
Tg(Tie1-cre)9Ref,
Tg(Tyr-cre/ERT2)13Bos,
Tg(Vav1-cre)1Cgp,
Tg(VAV1-cre)1Graf,
Tg(Vav1-cre)8Cgp,
Tg(Wfs1-cre/ERT2)3Aibs,
Tg(Zp3-cre)3Mrt,
Tlr2tm1(cre)Dfil,
Tlx1tm1.1(cre/ERT2)Rygo,
Tnfrsf11atm1(icre)Wask,
Tnfsf11em2(cre)Htaka,
Twist2tm1.1(cre)Dor,
Vwfem1(cre/ERT2)Cya,
Wt1tm1(EGFP/cre)Wtp,
Xcr1tm2.1(icre)Ciphe
(less)
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Recombinase Activity
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Click heading to re-sort table.
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References
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Analysis Tools