Tg(Tg-cre)1Soff - Embryo-other Recombinase Activity Detail MGI Mouse

Tg(Tg-cre)1Soff - Embryo-other
Recombinase Activity Detail

Allele Information | Images | Recombinase Activity | References

Allele Information

Allele:

Tg(Tg-cre)1Soff
transgene insertion 1, Stefan Offermanns

Driver: Tg
Type: Transgenic (Recombinase)

Synonym:

Tg-cre

Molecular description:

A transgenic construct with the coding sequence of the iCre recombinase followed by the bovine GH polyadenylation signal and a frt-flanked ampicillin cassette was fused to sequences from the proximal promoter and first intron of the mouse thyroglobulin (Tg) gene. The whole construct was introduced into the PAC encoding the Tg gene and by homologous recombination, the ATG of the iCre replaced the ATG of the thryoglobulin gene. The ampicillin cassette was removed by Flp-mediated recombination. Cre activity is observed in nearly all thyrocytes, but not in other cells of the thryoid gland after E10.5.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Additional Tissues:

Tg(Tg-cre)1Soff activity also observed in:
alimentary system, endocrine system

Images

Drag images to compare to others or to data in the table below. Drag corners to resize images for more detail. Reset Images

J:127484 Fig. 1

Recombinase Activity

Click heading to re-sort table.

Assays Genotypic Background Result Notes

References

All for this allele:

6 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23