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Tg(Cspg4-cre)1Akik - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Cspg4-cre)1Akik
transgene insertion 1, Akiko Nishiyama
Driver: Cspg4
Type: Transgenic (Recombinase)
Synonym: Cspg4(NG2)-Cre, ng2-Cre, NG2creBAC
Molecular description: The transgene construct consisted of the 208 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-309G21, containing the entire NG2 (Cspg4) gene (and 60 kbp of 5' and 114 kbp of 3' flanking sequences), which was modified by inserting an nls-cre coding sequence followed by a rabbit beta-globin polyA signal into the first exon of the NG2 gene. The NG2 translation initiation ATG was changed to AAG to prevent translation from the BAC NG2 gene and to allow translation from the first ATG in the cre sequence. Cre expression is detected only in Cspg4-expressing cells at P1, P14 and P60 and not in Gfap +ve astrocytes or APC +ve oligodendrocytes. Activity is also detected in male germ cells.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Cspg4-cre)1Akik activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:129201 Fig. 3 J:129201 Fig. 4 J:129201 Fig. 5 J:129201 Fig. 6 J:206504 Full image
Fig. Cspg4 Brain P56
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Fig. Cspg4 Sp Cord P56
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Fig. Cspg4 Vertebra/Sp Cord E15.5
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory