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Tg(NPHS2-rtTA,tetO-cre)1Holt - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Tg(NPHS2-rtTA,tetO-cre)1Holt
transgene insertion 1, Harry Holthofer 		Driver: NPHS2
Type: Transgenic (Inducible, Recombinase, Transactivator)
Inducer: doxycycline/tetracycline
Synonym: JRC-CRE
Molecular description: A rtTA gene modified to respond to less doxycycline was placed under the control of the human NPHS2 gene, which is only expressed in the podocytes of the kidney. In the same vector, a modified CMV promoter with a rtTA responsive element was used to drive the expression of cre recombinase. Sixteen founder mice were created, and one was selected for further breeding based on the doxycycline-induced expression of cre recombinase that was only detected in kidney podocyte cells.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(NPHS2-rtTA,tetO-cre)1Holt activity also observed in:
renal & urinary system
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory