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Mogtm1(cre)Gkl - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Mogtm1(cre)Gkl
myelin oligodendrocyte glycoprotein; targeted mutation 1, George Kollias 		Driver: Mog
Type: Targeted (Recombinase)
Synonym: MOGi-cre
Molecular description: The open reading frame of the Cre recombinase gene, followed by the human growth hormone polyadenylation signal and the neomycin resistance gene, has replaced all except the 5'-most segment of the first exon, the first intron and all but the 3'-most part of the second exon of the myelin oligodendrocyte glycoprotein gene, thus targeting Cre expression to oligodendrocytes (ODCs). Western blot analysis demonstrated that wild-type MOG protein is present in heterozygous and wild-type brains at comparable levels, but is not detectable in homozygous mutant brain.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Mogtm1(cre)Gkl activity also observed in:
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Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 20 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory