Tg(Tyr-cre/ERT2)13Bos - Nervous System Recombinase Activity Detail MGI Mouse

Tg(Tyr-cre/ERT2)13Bos - Nervous System
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Tg(Tyr-cre/ERT2)13Bos
transgene insertion 13, Marcus Bosenberg

Driver: Tyr
Type: Transgenic (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

Tyr::CreER, Tyr::CreER^T2, Tyr::CreER^T2-Bos

Molecular description:

This transgene consists of a 5.5 kb fragment of the Tyr promoter and a 3.6 kb fragment of the Tyr enhancer driving expression of a tamoxifen-inducible form of cre recombinase. 3 lines were generated which all showed tamoxifen-inducible Cre activity in cutaneous melanocytes. This is a representative record for all 3 lines. Line 13 contains 2 copies of the transgene inserted into chromosome 2 (chr2:129,989,606; NCBI37/mm9) 7.8 kb downstream of Snrpb and 9.6 kb downstream of Tgm6 with a 3 kb deletion at the integration site. In addition, three or more copies of the transgene were integrated on chromosome 2 resulting in ~3 kb deletion of this intergenic region between base pairs 130,160,936 and 130,163,877 [mouse mm10].

Find mice (IMSR):

Mouse Strains: 12 strains available Cell Lines: 0 lines available

Additional Tissues:

Tg(Tyr-cre/ERT2)13Bos activity also observed in:

alimentary system, endocrine system, head, hemolymphoid system ...(more)

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

152 reference(s)

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