About   Help   FAQ
Tg(Tyr-cre/ERT2)1Lru - Head
Recombinase Activity Detail
Allele Information
Allele:
Tg(Tyr-cre/ERT2)1Lru
transgene insertion 1, Lionel Larue 		Driver: Tyr
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Tg(Tyr-cre/ERT2)1Laru, Tyr::Cre-ERT2, Tyr::CreERT2-Lar
Molecular description: This transgene expresses a tamoxifen-inducible form of cre recombinase under the control of the tyrosinase enhancer and promoter, active in melanoblasts and melanocytes. The transgene inserted on the proximal end of chromosome 7 fused to a ~3 million base pair duplication from the proximal end of chromosome 2. This insertion also caused the deletion of some chromosome 7 loci. Specifically, the insertion occurred on chromosome 7 into exon 10 of the Nlrp12 locus (3,220,560; mouse mm10), causing deletion of centromeric sequences including the entire Speer9-ps1 and Au018091 loci as well as the remaining 3' Nlrp12 sequences. The duplicated chromosome 2 sequences (now fused to the transgene on chromosome 7) include the entire Fam171a1, Nmt2, Rpp38, Olah1, Meig1, and Dclre1c loci, as well as a portion of Suv39h2 lacking exons 1-2. Therefore, animals hemizygous for the Tg(Tyr-cre/ERT2)1Lru allele carries three copies of the duplicated chromosome 2 genes, but only one functional copy of the deleted chromosome 7 genes.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Tyr-cre/ERT2)1Lru activity also observed in:
embryo-other, integumental system
Images
Drag images to compare to others or to data in the table below. Drag corners to resize images for more detail. Reset Images
J:105276 Fig. 5 J:105276 Fig. 6
Recombinase Activity
Click heading to re-sort table.
Assays Genotypic Background Result Notes  
References
All for this allele: 31 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory