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Tg(Vil1-cre/ERT2)23Syr - Alimentary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Vil1-cre/ERT2)23Syr
transgene insertion 23, Sylvie Robine 		Driver: Vil1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: TgvCreERT2, Tg(Vil-cre/ESR1)23Syr, vil-Cre-ERT2, vil-Cre-ERT2, villin-creERT2, villin::CreERT2, Villin-Cre(ER-T2), Villin-CreERT2
Molecular description: A 9 kb segment of the regulatory region of the mouse Vil gene drives expression of cre recombinase fused to a mutated ligand-binding domain of the human estrogen receptor. Cre recombination is inducible with tamoxifen treatment in epithelial cells all along the crypt-villus axis and in undifferentiated progenitor cells in the crypt region. This is a representative record for the two lines generated (Fo23 and Fo24) that have the same inducible expression pattern. Only 1 copy of the transgene is integrated into these lines.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Tissue Information
Alimentary System Other recombinase alleles with activity in Alimentary System tissues:
Images
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J:92295 Fig. 5
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 425 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory