A1cf<Tg(Myh6-cre/Esr1*)1Jmk> - Head Recombinase Activity Detail MGI Mouse

A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} - Head
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}
APOBEC1 complementation factor; transgene insertion 1, Jeffery D Molkentin

Driver: Myh6
Type: Transgenic (Inducible, Null/knockout, Recombinase)

Inducer:

tamoxifen

Synonym:

alphaMHC-Cre-Mer-Cre, alpha-MHC-MerCreMer, CM-MCM, MCM, mer, mER-CRE-mER, MerCreMer, Myh6-MerCreMer, Myh6:MerCreMer, Tg(Myh6-cre/Esr1)1Jmk

Molecular description:

This transgene expresses a cre recombinase/ mutant estrogen receptor ligand binding domain fusion protein under the control of a mouse cardiac-specific alpha-myosin heavy chain promoter. Expression was detected in the juvenile and adult heart, but the protein is inactive until induced with tamoxifen. Integration of the transgene in to Chr. 19 deleted a 19,500 bp fragment including the promoter, exon 1, and part of intron 1 of the A1cf gene. Western analysis of liver from homozygous transgenic mice does not detect A1cf protein.

Find mice (IMSR):

Mouse Strains: 5 strains available Cell Lines: 0 lines available

Additional Tissues:

A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} activity also observed in:
cardiovascular system, muscle

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

474 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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