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Tg(Itga2b-cre)NE1/21Emam - Liver And Biliary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Itga2b-cre)NE1/21Emam
transgene insertion NE1/21, Nikla R Emambokus
Driver: Itga2b
Type: Transgenic (Recombinase)
Synonym: gpIIb-Cre
Molecular description: The transgenic construct was comprised of an integrin alpha 2b genomic fragment, including 2.5 kb of promoter through 2.8 kb of intron 1, adjoined to sequence encoding cre recombinase with a nuclear localization signal. The cassette containng NLS-cre also contained a splice acceptor site, IRES, and a polyadenylation signal. The integrin alpha 2b promoter drives expression of cre recombinase at the site of emergence of hematopoietic progenitors in the yolk sac, aorta-gonad-mesonephros region, and fetal liver. Founder mice contained between 2 and 5 copies of the transgene.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Itga2b-cre)NE1/21Emam activity also observed in:
cardiovascular system, embryo-other, extraembryonic component, hemolymphoid system, renal and urinary system
Tissue Information
Liver And Biliary System Other recombinase alleles with activity in Liver And Biliary System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory