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Allele Information
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Allele:
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Tg(tetO-cre)LC1Bjd
transgene insertion LC1, Hermann Bujard
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Driver: tetO
Type: Transgenic
(Inducible, Recombinase)
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Inducer:
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doxycycline/tetracycline
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Synonym:
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LC-1, LC1-Cre, TgLC1, TRE-LC1
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Molecular description:
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The transgenic construct contained a bidirectional tTA/rtTA responsive promoter derived from the human cytomegalovirus promoter IE and flanked by sequence encoding luciferase and cre recombinase. Efficient cre mediated recombination, unaffected by position effect variegation, was demonstrated in hepatocytes. Transcription of in both directions was shown to be activated by rtTA in the presence of doxycycline. Transgene insertion is on chromosome 6C1 flanked by genes coding for the
vomeronasal receptors V1rc14 and V1rc15 (K.Schonig, pers. commun.)
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Find mice (IMSR):
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Mouse Strains:
2
strains available
Cell Lines:
0 lines available
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Additional Tissues:
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Tg(tetO-cre)LC1Bjd activity also observed in:
head,
nervous system,
renal & urinary system,
respiratory system
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Tissue Information
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Liver & Biliary System
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Other recombinase alleles with activity in Liver & Biliary System tissues:
Abcg2tm1.1(cre/Esr1*)Jvbe,
Albem1(dre/ERT2)Bzsh,
Albtm1(cre/ERT2)Mtz,
Albtm1(cre/ERT2)Smoc,
Aldh1l1em1(cre/ERT2)Nju,
Alpltm1(cre)Nagy,
Aplnrem3(cre/ERT2)Smoc,
Ccktm1.1(cre)Zjh,
Cd34tm1.1(cre/ERT2)Lizg,
Cd40lgtm1.1(cre)Tega,
Cdh5em1(cre/ERT2)Smoc,
Cdh5em1(nigri)Bzsh,
Cdkn2atm1.1(cre)Dvb,
Cdkn2atm1(cre/ERT2)Mkt,
Cdkn2atm2.1(cre/ERT2)Dvb,
Cldn6tm1(cre/ERT2)Dam,
Clutm2(EGFP/cre/ERT2)Wtsi,
Commd10Tg(Vav1-icre)A2Kio,
Crybb1em1(icre)Cln,
Cx3cr1tm1.1(cre)Jung,
Cx3cr1tm2.1(cre/ERT2)Jung,
Ddx4em1(icre)Jobo,
E2f1Tg(Wnt1-cre)2Sor,
Eportm1.1(EGFP/icre)Uk,
Epxtm1.1(cre)Jlee,
Fgf18tm2.2(cre/ERT2)Dor,
Fgf21em1(cre)Mpot,
Flt4tm2.1(cre/ERT2)Sgo,
Foxa2tm1(cre)Heli,
Foxa2tm2.1(cre/Esr1*)Moon,
Gad2tm2(cre)Zjh,
Gata4tm2(cre/ERT2)Ykaw,
Gfi1tm1(cre)Gan,
Glp1rtm1.1(cre)Cors,
Golm1tm2(EGFP/cre/ERT2)Wtsi,
Gt(ROSA)26Sorem1(CAG-Ncre/vvd*,-vvd*/Ccre)Larc,
Gt(ROSA)26Sortm1.1(CAG-cre)Jphe,
Gt(ROSA)26Sortm13(dreo)Maoh,
Gt(ROSA)26Sortm14.1(Thy1-dre)Maoh,
Gt(ROSA)26Sortm1(cre/ERT2)Tyj,
Gt(ROSA)26Sortm1(cre/ERT)Brn,
Gt(ROSA)26Sortm2(cre/ERT2)Brn,
Gt(ROSA)26Sortm2(icre/ERT2)Jphe,
Gt(ROSA)26Sortm5(dre)Dwi,
Gt(ROSA)26Sortm6(dre/PGR*)Dwi,
Gt(ROSA)26Sortm8(CAG-dre/ERT2)Bzsh,
H2az2Tg(Wnt1-cre)11Rth,
Hlfem1(cre/ERT2)Smoc,
Hlfem2(cre/ERT2)Suda,
Hnf4aem1(dre/ERT2)Bzsh,
Hnf4atm1(cre)Sdv,
Hprt1tm1(CAG-cre)Mnn,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Igs2tm1(Cdkn1a-cre/ERT2,-EGFP)Mxu,
Ihhem1(Tomm20/mKate2,dre)Xya,
Il25tm2.1(icre)Lky,
Il25tm3.1(cre/ERT2)Lky,
Krt17tm1(cre)Murr,
Krt19tm1(cre/ERT)Ggu,
Lect2em1(cre)Smoc,
Leprtm2(cre)Rck,
Ltftm1(icre)Tdku,
Ly6atm2.1(cre/Esr1*)Jmol,
Lyve1tm1.1(EGFP/cre)Cys,
Lyz2tm1(cre)Ifo,
Mecomem1(cre/ERT2)Suda,
Mecomtm4.1(cre/ERT2)Aspe,
Mfsd2aem1(cre/ERT2)Bzsh,
Mfsd2aem2(cre/ERT2)Bzsh,
Myf5tm3(cre)Sor,
Myh6em2(cre)Smoc,
Ndor1Tg(UBC-cre/ERT2)1Ejb,
Nkx2-5tm2(cre)Rph,
Osr2tm2(cre)Jian,
P2ry12em1(icre/ERT2)Tda,
Pbx3tm1(EGFP/cre/ERT2)Wtsi,
Pdgfratm1.1(EGFP/cre/ERT2)Hyma,
Pdx1tm1.1(flpo)Most,
Piezo1em2(cre/ERT2)Smoc,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Pms2tm2(cre)Lisk,
Prlrtm1.1(cre)Uboe,
Ptf1atm1.1(cre)Cvw,
Rbpmsem1(cre/ERT2)Yzhe,
Runx1tm1(cre/Esr1*)Ims,
Shhtm1(EGFP/cre)Cjt,
Sox17tm1(icre)Heli,
Sox17tm2.1(icre)Heli,
Sox17tm4.1(icre/ERT2)Heli,
Sox2tm1.1(cre/ERT2)Ykaw,
Speer6-ps1Tg(Alb-cre)21Mgn,
Spink1tm3(cre)Kymm,
Sptbtm2(EGFP/cre/ERT2)Wtsi,
Taglntm2(cre)Yec,
Tbx21tm1.1(cre/ERT2)Ayr,
Tbx3em1(cre/ERT2)Toyo,
Tekem1(dre)Bzsh,
Tektm1.1(icre/Esr1*)Hrr,
Tg(Acp5-cre)3Rda,
Tg(Acp5-cre)4Rda,
Tg(ACTA1-cre)79Jme,
Tg(ACTB-cre)1Tes,
Tg(Acvrl1-cre)B1Spo,
Tg(Alb1-cre)1Dlr,
Tg(Alb1-cre)7Gsc,
Tg(Alb-cre/ERT2)#Nor,
Tg(Aldh1l1-cre/ERT2)02Kan,
Tg(Amy2-cre)1Herr,
Tg(CAG-cre/Esr1*)1Lbe,
Tg(CAG-cre/Esr1*)5Amc,
Tg(CAG-cre/Esr1*)86Lbgn,
Tg(Car1-cre)5Flt,
Tg(Ccr2-cre/ERT2)12Kuan,
Tg(CD2-icre)4Kio,
Tg(Cdh16-cre)91Igr,
Tg(Cdh5-cre)1Nmoc,
Tg(Cdh5-cre)1Spe,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(CDX2-cre)101Erf,
Tg(Chst4-cre)1Hkwa,
Tg(CMV-cre)1Cgn,
Tg(Col1a2-cre)23Angl,
Tg(Csf1r-cre/Esr1*)1Jwp,
Tg(Csf1r-icre)1Jwp,
Tg(Ctgf-cre)2Aibs,
Tg(Ctsk-cre)8Rda,
Tg(Cyp17a1-icre)AJako,
Tg(Cyp19a1-cre)5909Gle,
Tg(Cyp1a1-cre)1Dwi,
Tg(Cyp1a1-cre/ERT)1Dwi,
Tg(Cyp39a1-cre)1Aibs,
Tg(Ddx4-cre)1Dcas,
Tg(EIIa-cre)C5379Lmgd,
Tg(Eno2-cre)39Jme,
Tg(Epo-cre)44Mym,
Tg(Etv2-cre)15508Djg,
Tg(Fabp1-cre)1Jig,
Tg(Fabp4-cre)1Rev,
Tg(Fgfr3-icre/ERT2)4-2Wdr,
Tg(Foxl1-cre)1Khk,
Tg(Gata1-cre)1Sho,
Tg(GATA5-cre)1Krc,
Tg(GFAP-cre)25Mes,
Tg(Glp1r-icre)#Fmgb,
Tg(Grik4-cre)G32-4Stl,
Tg(HBB-cre)12Kpe,
Tg(HBB-cre)27038Kpe,
Tg(HBB-cre)27053Kpe,
Tg(Hspa2-cre)1Eddy,
Tg(Il7-cre)CRche,
Tg(Ins2-cre)25Mgn,
Tg(Islr-cre/ERT2)#Tobe,
Tg(Itga2b-cre)AParl,
Tg(Itga2b-cre)NE1/21Emam,
Tg(Itgax-cre)1-1Reiz,
Tg(Kap-icre)29066/2Sig,
Tg(Kdr-cre)15962Brei,
Tg(KRT14-cre)1Amc,
Tg(KRT18-cre/ERT2)1Rgo,
Tg(Krt19-icre)2Hirt,
Tg(Krt8-cre/ERT2,-GFP)1Xin,
Tg(Lck-icre)3779Nik,
Tg(LPAR4-cre/ERT2,-EGFP)#Hjcho,
Tg(Lrat-cre)1Rshw,
Tg(Mafg-Nrf2/cre,-EGFP)737Hozu,
Tg(MMTV-cre)4Mam,
Tg(Mx1-cre)1Cgn,
Tg(Mx1-cre)29-4Her,
Tg(MYOD1-cre)M23Glh,
Tg(Ncr1-cre/ERT2)#Lll,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Nkx2-5-cre)9Eno,
Tg(Nrp2-cre,-EGFP)#Qsch,
Tg(Pcp2-cre)1Amc,
Tg(Pcp2-cre)2Mpin,
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut,
Tg(Pf4-icre)Q3Rsko,
Tg(Prdm1-cre)1Masu,
Tg(Prox1-cre/ERT2)1Tmak,
Tg(Prrx1-cre)1Cjt,
Tg(REN-cre)1Haca,
Tg(Retnla-cre)#Voeh,
Tg(Runx1/Hspa1a-cre/ERT2)#Itoy,
Tg(S100a4-cre)1Egn,
Tg(SERPINA1-cre)1Arge,
Tg(SERPINA1-cre/ERT)1Ipc,
Tg(Sim1-cre)1Lowl,
Tg(Spp1-icre/ERT2)#Lecl,
Tg(Stab2-icre)1.2Cger,
Tg(Tagln-cre)1Her,
Tg(Tagln-cre)1Jjl,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tal1-cre/ERT)42-056Jrg,
Tg(Tek-cre)12Flv,
Tg(Tek-cre)1Arnd,
Tg(Tek-cre)1Ywa,
Tg(Tek-cre)5326Sato,
Tg(Tek-cre/ERT2)1Arnd,
Tg(Tek-icre/ERT2)1Soff,
Tg(Thy1-cre)1Vln,
Tg(Thy1-cre)703Vaw,
Tg(Tie1-cre)9Ref,
Tg(Tshb-cre)4Sac,
Tg(Ttr-cre/Esr1*)1Vco,
Tg(VAV1-cre)1Graf,
Tg(Wfs1-cre/ERT2)3Aibs,
Tg(Zp3-cre)3Mrt,
Tlr2tm1(cre)Dfil,
Tmprss2tm1.1(cre/ERT2)Ychen,
Tnfrsf19tm1.1(cre/ERT2)Cle,
Trem2em1(cre)Jddl,
Twist2tm1.1(cre)Dor,
Vil1em1(flpo)Lbrl,
Wt1tm1(EGFP/cre)Wtp
(less)
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Recombinase Activity
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References
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Analysis Tools