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Tg(Vil1-cre)997Gum - Renal & Urinary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Vil1-cre)997Gum
transgene insertion 997, Deborah L Gumucio 		Driver: Vil1
Type: Transgenic (Recombinase)
Synonym: 12.4KbVilCre, Tg(Vil-cre)997Gum, Vcre, VilCre, Vil-Cre, Villin-cre, Villin.cre, VillinCre
Molecular description: A 12.4-kb promoter fragment from the villin 1 gene drives the expression of cre recombinase cDNA with the entire metallothionein sequence and a poly(A) signal. Recombination occurs in villi and crypt cells of the small and large intestines, closely patterning the endogenous gene expression. Seven lines were generated. According to the corresponding author (J:78815), expression is generally continuous but a small amount of mosaicism is noted in the colon. Onset of transgene expression is at 12.5 dpc, which is delayed from the endogenous mouse Vil gene expression onset of 9.0 dpc. Line 997 contains 16 copies of the transgene inserted in chromosome 17 about 119 kb upstream of St6gal2 (chr17:55,466,255; NCBI37/mm9) with a 14.6 kb deletion at the integration site.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Vil1-cre)997Gum activity also observed in:
Tissue Information
Renal & Urinary System Other recombinase alleles with activity in Renal & Urinary System tissues:
Images
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J:184579 Full Image
Fig. Vil Kidney P56 J:184579 Full Image
Fig. Vil Kidney P7 J:184579 Full Image
Fig. Vil Metanephros E15.5
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 644 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory