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Tg(Thy1-cre/PGR)1Gsc - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Thy1-cre/PGR)1Gsc
transgene insertion 1, Gunther Schutz
Driver: Thy1
Type: Transgenic (Inducible, Recombinase)
Inducer: induced by RU486 (mifepristone)
Synonym: TPR1
Molecular description: This transgene expresses a fusion protein consisting of Cre recombinase and a modified ligand binding domain of the human progesterone receptor under the control of a mouse Thy1 promoter. The ligand binding domain was modified such that it binds and can be activated by the synthetic steroid, RU486, but not the endogenous ligand, progesterone. Upon induction of transgene expression with RU486, activity was noted in the hippocampus and cortex. Activity was also noted in small populations of cells in the inferior colliculus, the striatum, the thalamus, the brain stem, and the cerebellum.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory