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Allele Information
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Allele:
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Tg(Tagln-cre)1Her
transgene insertion 1, Joachim Herz
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Driver: Tagln
Type: Transgenic
(Recombinase)
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Synonym:
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SM, SM22a-Cre, Sm22alphaCre, SM22-Cre, SM22-Cretg, Tag1-Cre, Tgln-Cre
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Molecular description:
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The transgene consists of a Tagln (transgelin) promoter and a cre gene modified to include translational consensus and nuclear localization signals. The Tagln promoter was used to drive transgene expression in smooth muscle cells. Cre recombinase mRNA expression closely patterns endogenous transgelin expression, with the highest levels detected in the aorta, intestine, and uterus. Low levels of Cre recombinase transcript are detected in all other organs. Recombination occurs in vascular smooth muscle cells of hepatic and pulmonary arteries. No recombination has been detected in non-muscle cells.
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Find mice (IMSR):
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Mouse Strains:
2
strains available
Cell Lines:
0 lines available
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Additional Tissues:
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Tg(Tagln-cre)1Her activity also observed in:
adipose tissue,
alimentary system,
branchial arches,
cardiovascular system,
embryo-other,
endocrine system,
extraembryonic component,
head,
hemolymphoid system,
integumental system,
limbs,
liver & biliary system,
mesenchyme,
muscle,
nervous system,
renal & urinary system,
reproductive system,
respiratory system,
sensory organs,
skeletal system,
tail
(less)
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Tissue Information
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Cavities & Their Linings
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Other recombinase alleles with activity in Cavities & Their Linings tissues:
Alpltm1(cre)Nagy,
Atoh8tm1(EGFP/cre)Gasa,
Bhlhe41em1(cre)Cya,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Cdh5em1(cre/ERT2)Smoc,
Cx3cr1tm1.1(cre)Jung,
Cx3cr1tm2.1(cre/ERT2)Jung,
En1tm2(cre)Wrst,
Flt4tm2.1(cre/ERT2)Sgo,
Foxd1tm1(GFP/cre)Amc,
Gt(ROSA)26Sortm1(cre/ERT)Brn,
H2az2Tg(Wnt1-cre)11Rth,
Hand1tm1.1(EGFP/cre)Abfi,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Igs2tm2(Smarcd3-cre/ERT2)Bbr,
Mecomtm4.1(cre/ERT2)Aspe,
Myf5tm3(cre)Sor,
Nfatc1em4(cre/ERT2)Bzsh,
Nkx2-5tm2(cre)Rph,
Npr3em1(cre/ERT2)Bzsh,
Osr2tm2(cre)Jian,
Pax3tm1(cre)Joe,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Pmelem1(rtTA,tetO-icre)Osaw,
Scxtm1.1(cre)Shuk,
Sfrp5tm1.1(cre)Kkb,
Slc17a6tm2(cre)Lowl,
Taglntm2(cre)Yec,
Tg(ACTA1-cre)79Jme,
Tg(ACTA1-cre/Esr1*)2Kesr,
Tg(CAG-cre/Esr1*)5Amc,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(CDX2-cre)101Erf,
Tg(Ctgf-cre)2Aibs,
Tg(Ddx4-cre)1Dcas,
Tg(dlx5a-cre)1Mekk,
Tg(EIIa-cre)C5379Lmgd,
Tg(Eno2-cre)39Jme,
Tg(Epx-EYFP/cre)#Voeh,
Tg(Fabp4-cre)1Rev,
Tg(Flt1-cre/ERT2)1Tmak,
Tg(Gata4*G2-cre)#Roja,
Tg(GATA5-cre)1Krc,
Tg(Grik4-cre)G32-4Stl,
Tg(Hand1-EGFP/cre)#Abfi,
Tg(Hspa2-cre)1Eddy,
Tg(KRT14-cre)1Amc,
Tg(Mef2c-cre)1Blk,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Pdzk1ip1-cre/ERT2)#Reiz,
Tg(Pf4-icre)Q3Rsko,
Tg(Prrx1-cre)1Cjt,
Tg(Retnla-cre)#Voeh,
Tg(Sim1-cre)1Lowl,
Tg(Smarcd3-cre/ERT2)#Bbr,
Tg(Tbx18-icre)3Fech,
Tg(Tek-cre)1Ywa,
Tg(Thy1-cre)1Vln,
Tg(Wnt11-cre/ERT2)1Jwng,
Tg(WT1-cre)AG11Dbdr,
Tg(Wt1-cre)#Jbeb,
Twist2tm1.1(cre)Dor,
Twist2tm1(cre/ERT2)Eno,
Wt1em1(cre/ERT2)Bzsh,
Wt1tm1(EGFP/cre)Wtp,
Wt1tm2(cre/ERT2)Wtp
(less)
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Recombinase Activity
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References
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Analysis Tools