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Gt(ROSA)26Sortm1(cre/ERT)Brn - Cavities And Their Linings
Recombinase Activity Detail
Allele Information
Allele:
Gt(ROSA)26Sortm1(cre/ERT)Brn
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Anton Berns
Driver: Gt(ROSA)26Sor
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: ACM-cre, Cre-ERTm, Gt(ROSA)26Sortm1(cre/Esr1)Brn, R26cre-ERT, R26-CreERT, R26Cre-ERT, Tx-Cre
Molecular description: The endogenous locus was modified by insertion of a construct containing the rabbit beta-globin 3' splice site followed by the cre/ERT fusion gene, which encodes Cre recombinase joined to the G321R mutant hormone-binding domain of the human estrogen receptor that is activated by 4-hydroxytamoxifen (4-OHT), but not by the natural ER ligand 17-beta-estradiol. The fusion gene is followed by the rabbit beta-globin polyadenylation signal and a PGK-puro (puromycin resistance) cassette. Efficient Cre-mediated recombination in transgenic mice carrying floxed reporter genes was reported to reflect constitutive expression of the Gt(ROSA)26Sor from preimplantation stages onward.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Gt(ROSA)26Sortm1(cre/ERT)Brn activity also observed in:
alimentary system, integumental system, liver and biliary system, renal and urinary system, respiratory system
Tissue Information
Cavities And Their Linings Other recombinase alleles with activity in Cavities And Their Linings tissues:
Images
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J:143936 Fig. 1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory