Tagln<tm1(cre/ERT2)Feil> - Head Recombinase Activity Detail MGI Mouse

Tagln^{tm1(cre/ERT2)Feil} - Head
Recombinase Activity Detail

Allele Information | Images | Recombinase Activity | References

Allele Information

Allele:

Tagln^{tm1(cre/ERT2)Feil}
transgelin; targeted mutation 1, Robert Feil

Driver: Tagln
Type: Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

SM22alphaCew-ER^T2, SM-Cre ER^T2(ki), SM-CreER^T2(ki), SM-CreERT2(ki), Tagln^{tm1(cre/ESR1)Feil}

Molecular description:

An allele encoding a tissue specific and ligand dependent recombinase was generated by inserting cre recombinase/modified estrogen receptor (ESR1) fusion sequence into the endogenous allele. The ESR1 sequence contained engineered missense mutations at positions 400, 543, 540 which substituted the ability to bind the endogenous ligand with the ability to bind tamoxifen (J:79835). Histochemical analysis of mutant mice treated with tamoxifen showed expression of cre in smooth muscle tissue.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Additional Tissues:

Tagln^{tm1(cre/ERT2)Feil} activity also observed in:
alimentary system, cardiovascular system, muscle

Images

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J:69325 Fig. 3

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

36 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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