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Allele Information
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Allele:
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Inducer:
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induced by tamoxifen
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Synonym:
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Tg(Tagln-cre/ESR1)1Feil, SM-CreERT2(tg)
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Molecular description:
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An allele encoding a tissue specific and ligand dependent recombinase was generated by adjoining cre recombinase/modified estrogen receptor (ESR1) fusion sequence to 5.5 kb of the transgelin promoter and regulatory region. The ESR1 sequence contained engineered missense mutations at positions 400, 543, 540 which substituted the ability to bind the endogenous ligand with the ability to bind tamoxifen (J:79835). The Tagln promoter directed expression in smooth muscle cells. Transgenic expression was detected in smooth muscle tissue, but was characterized as being low and mosaic. Recombination was tamoxifen dependent.
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Find mice (IMSR):
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Mouse Strains:
0 lines available
Cell Lines:
0 lines available
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Tissue Information
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Cardiovascular System
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Other recombinase alleles with activity in Cardiovascular System tissues:
1700009P17Riktm1.1(icre)Heli,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Crhtm1(cre)Zjh,
Eportm1(EGFP/cre)Uk,
Fgf16tm1.1(cre)Sms,
Foxa2tm2.1(cre/Esr1*)Moon,
Gad2tm2(cre)Zjh,
Gt(ROSA)26Sortm1.1(cre)Jphe,
Gt(ROSA)26Sortm1(cre/ERT2)Tyj,
Gt(ROSA)26Sortm2(cre/ERT2)Brn,
Gt(ROSA)26Sortm2(icre/ERT2)Jphe,
Hcn4tm1(cre/ERT2)Anlu,
HhatTg(TFAP2A-cre)1Will,
Hprttm1(cre)Mnn,
Hsd11b2tm1(cre)Anft,
Isl1tm1(cre/Esr1*)Krc,
Isl1tm1(cre)Tmj,
Kdrtm1(cre)Sato,
Krt19tm1(cre)Mmt,
Lyz2tm1(cre)Ifo,
Mcm2tm1(cre/ERT2)Scpr,
Meox1tm1(cre)Jpa,
Mnx1tm4(cre)Tmj,
Myf5tm3(cre)Sor,
Myl2tm1(cre)Krc,
Myocdtm1(cre)Jomm,
Nkx2-5tm1(cre)Rjs,
Nkx2-5tm2(cre)Rph,
Notch1tm3(cre)Rko,
Omptm4(cre)Mom,
Pax3tm1(cre)Joe,
Pitx2tm4(cre)Jfm,
Pvalbtm1(cre)Arbr,
Runx1tm1(cre/Esr1*)Ims,
Runx1tm2.1(cre/Esr1*)Ims,
Shhtm1(EGFP/cre)Cjt,
Sox17tm1(icre)Heli,
Sox17tm2.1(icre)Heli,
Ssttm2.1(cre)Zjh,
Taglntm1(cre/ERT2)Feil,
Taglntm2(cre)Yec,
Tbx1tm4(cre/Esr1*)Bld,
Tg(Acp5-cre)4Rda,
Tg(ACTA1-cre)79Jme,
Tg(ACTA2-cre)1Miwa,
Tg(Acta2-cre/ERT2)12Pcn,
Tg(Acta2-cre/ERT2)51Pcn,
Tg(ACTB-cre)1Tes,
Tg(ACTC1-cre)1Miwa,
Tg(ACTFLPe)9205Dym,
Tg(Acvrl1-cre)B1Spo,
Tg(Acvrl1-cre)L1Spo,
Tg(Akr1b7-cre)1Anm,
Tg(Alb1-cre)1Dlr,
Tg(CAG-cre/Esr1*)1Lbe,
Tg(CAG-cre/Esr1*)5Amc,
Tg(CAG-cre/Esr1*)86Lbgn,
Tg(Camk2a-cre)1Nobs,
Tg(CD2-cre)4Kio,
Tg(Cdh5-cre)1Nmoc,
Tg(Cdh5-cre)1Spe,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)1Rha,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(Cga-cre)3Sac,
Tg(Chst4-cre)1Hkwa,
Tg(CMV-cre)1And,
Tg(CMV-cre)1Cgn,
Tg(Col1a2-cre)23Angl,
Tg(Col1a2-cre/ERT)7Cpd,
Tg(Col2a1-cre)1Asz,
Tg(COL2A1-cre)1Wag,
Tg(Col6a1-cre)1Gkl,
Tg(Csf1r-icre)1Jwp,
Tg(Csrp1-cre)1Sjc,
Tg(Cyp19a1-cre)5909Gle,
Tg(DBH-cre)9-9Koba,
Tg(Dbh-icre)1Gsc,
Tg(Dhh-cre)1Mejr,
Tg(Dll1-cre)33Dchp,
Tg(EIIa-cre)C5379Lmgd,
Tg(Fabp4-cre)1Rev,
Tgfb3tm1(cre)Vk,
Tg(Frzb-cre)1Tylz,
Tg(Fzd9-cre)1Chzh,
Tg(Gata1-cre)1Sho,
Tg(GATA5-cre)1Krc,
Tg(GATA6-cre)#Jbeb,
Tg(GFAP-cre)25Mes,
Tg(Grik4-cre)G32-4Stl,
Tg(Hand2-cre)7-1Clou,
Tg(Hoxb2-cre)1Ksec,
Tg(Hsp70-1-cre)6Arge,
Tg(Hspa2-cre)1Eddy,
Tg(Ins2-cre)25Mgn,
Tg(Itga2b-cre)NE1/21Emam,
Tg(Kcne1-cre/ERT2)1Imos,
Tg(Kdr-cre)15962Brei,
Tg(Kdr-cre)15964Brei,
Tg(KRT14-cre)1Amc,
Tg(KRT14-cre/ERT)20Efu,
Tg(Leftb-cre)1Hmd,
Tg(Mbp-cre)9Gvn,
Tg(Mbp-cre,CAG-EGFP)53Masa,
Tg(Mef2c-cre)2Blk,
Tg(MMTV-cre)4Mam,
Tg(Mpz-cre)94Imeg,
Tg(Mx1-cre)1Cgn,
Tg(Mx1-cre)29-4Her,
Tg(Myh11-cre)5013Gko,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Myh11-cre/ERT2)1Soff,
Tg(Myh6-cre)2182Mds,
Tg(Myh6-cre/Esr1*)1Jmk,
Tg(Myh6-cre/PGR*)1Mds,
Tg(Myh6-cre/PGR*)6297Mds,
Tg(Myh7-cre)1Zli,
Tg(Myhc-cre)1Xya,
Tg(myl2-cre)1118Tmhn,
Tg(myl2-cre)1141Tmhn,
Tg(MYOD1-cre)M23Glh,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Nkx2-5-cre)9Eno,
Tg(Nppa-cre)3Vmc,
Tg(Nppa-cre)4Vmc,
Tg(Osr1-cre)4Mrt,
Tg(Pax3-cre)1Joe,
Tg(Pcp2-cre)1Amc,
Tg(Pcp2-cre)2Mpin,
Tg(Pdgfb-icre/ERT2)1Frut,
Tg(Pf4-cre)Q3Rsko,
Tg(Plp1-cre/ERT)3Pop,
Tg(Postn-cre)1Sjc,
Tg(REN-cre)1Haca,
Tg(rtetR-tetO-cre)1Mhz,
Tg(S100b-cre)20Ito,
Tg(Sftpa1-cre)1Xya,
Tg(Sim1-cre)1Lowl,
Tg(Slco1c1-icre/ERT2)1Mrks,
Tg(Smad7-cre)1Sjc,
Tg(Sox10-cre)1Wdr,
Tg(Sox10-cre)507Mcln,
Tg(Tagln-cre)1Her,
Tg(Tagln-cre)1Jjl,
Tg(Tagln-cre)1Jomm,
Tg(Tagln-cre)1Llw,
Tg(Tagln-rtTA-cre)1Llw,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tbx18-icre)1Fech,
Tg(Tbx1-cre)1Joe,
Tg(T-cre)1Lwd,
Tg(Tek-cre)12Flv,
Tg(Tek-cre)1Arnd,
Tg(Tek-cre)1Ywa,
Tg(Tek-cre)2352Rwng,
Tg(Tek-cre)5326Sato,
Tg(Tek-cre/ERT2)1Arnd,
Tg(Tek-cre)#Xya,
Tg(Thy1-cre)1Vln,
Tg(Thy1-cre)703Vaw,
Tg(Tie1-cre)9Ref,
Tg(Tnni3-cre/GFP)1Mknn,
Tg(Tnnt2-cre)5Blh,
Tg(Vav1-cre)1Awr,
Tg(Vav1-cre)1Cgp,
Tg(Vav1-cre)1Graf,
Tg(Vav1-cre)8Cgp,
Tg(Vil-cre)997Gum,
Tg(Wfs1-cre/ERT2)3Aibs,
Tg(Wnt1-cre)11Rth,
Tg(WT1-cre)AG11Dbdr,
Tg(Zp3-cre)3Mrt,
Thtm1(cre)Te,
Twist2tm1.1(cre)Dor,
Viptm1(cre)Zjh
(less)
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J:69325
Fig. 2
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Recombinase Activity
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Click heading to resort table.
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References
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Analysis Tools