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Tg(SERPINA1-cre/ERT)1Ipc - Liver And Biliary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(SERPINA1-cre/ERT)1Ipc
transgene insertion 1, I Pierre Chambon
Driver: SERPINA1
Type: Transgenic (Cre/Flp)
Inducer: induced by tamoxifen
Synonym: alphaAT-cre-ERT, Tg(SERPINA1-cre/ESR1)1Ipc
Molecular description: This transgenic construct encodes a tamoxifen inducible cre recombinase protein. A human SERPINA1 promoter was adjoined to sequence encoding a fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand binding domain, to drive expression in hepatocytes. The ligand binding domain posesses a substitution mutation at position 521, converting the region from an estradiol binding domain to a tamoxifen binding domain. In situ hybridization and immunohistochemical analysis showed expression in 40% to 50% of hepatocytes.
Find mice (IMSR): Mouse Strains: 0 lines available       Cell Lines: 0 lines available
Tissue Information
Liver And Biliary System Other recombinase alleles with activity in Liver And Biliary System tissues:
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J:69327 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory