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Tg(CAG-cre/Esr1*)5Amc - Renal And Urinary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(CAG-cre/Esr1*)5Amc
transgene insertion 5, Andrew P McMahon
Driver: CAG
Type: Transgenic (Inducible, Recombinase)
Inducer: Induced by tamoxifen.
Synonym: CAG-CreERT2, CAGG-Cre, CaggCreER, CAGGCre-ER, CAGG-CreERT2, CAGGCre-ERTM, CAGGCre-ERtm line 5.8, CAGGS-CreER, CAGGS-CreErT, CMV-creERT, Cre-ER, Cre-ERTM, CreESRT, ER-cre, Tg(CAG-cre/Esr1)5Amc, TgCAGGCreER, TgCreER, Tg(cre/Esr1)5Amc, uCreERT
Molecular description: This transgene expresses a fusion protein consisting of Cre recombinase joined to the ligand-binding domain of a mouse estrogen receptor modified to bind to 4-hydroxytamoxifen, but not to endogenous estrogen. The CAG promoter, containing a chicken beta actin promoter/enhancer coupled with the cytomegalovirus immediate-early (CMV-IE) enhancer, drives high levels of expression in most tissues. In the presence of tamoxifen, the fusion protein is transported into the nucleus, where cre can excise loxP-flanked segments from conditionally modified genes.
Find mice (IMSR): Mouse Strains: 6 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(CAG-cre/Esr1*)5Amc activity also observed in:
Tissue Information
Renal And Urinary System Other recombinase alleles with activity in Renal And Urinary System tissues:
Images
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J:76130 Fig. 6 J:76130 Fig. 7
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 254 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory