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Tg(Tek-cre)12Flv - Respiratory System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Tek-cre)12Flv
transgene insertion 12, Richard A Flavell 		Driver: Tek
Type: Transgenic (Null/knockout, Recombinase)
Synonym: btie2-cre, CreTek, Tek-Cre, Tet-cre, Tie2-Cre, Tie2-Cre, TIE2/cre, TIE2Cre, TIE2Cre+, Tie2(Tek)-Cre
Molecular description: Cre recombinase expression is driven by a mouse endothelial-specific receptor tyrosine kinase promoter/enhancer. Recombinase activity is detected in endothelial cells during embryogenesis and adulthood. Expression was also detected in hematopoietic cells. The promoter has also been reported to be active in female germ cells. A low frequency of deletion events are also observed by inheritance from the male germline. The transgene integrated into chromosome 13 causing a 241.3 Kb deletion and disrupting the following genes: Mtrr (5-methyltetrahydrofolate-homocysteine methyltransferase reductase), Fastkd3 (FAST kinase domains 3), 1700001L19Rik, Adcy2 (adenylate cyclase 2). The deletion results in a functional knock-out of Mtrr, Adcy2 and Fastkd3 in homozygous mice. Founder line 12 has a copy number of greater than 10.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Tek-cre)12Flv activity also observed in:
Tissue Information
Respiratory System Other recombinase alleles with activity in Respiratory System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 382 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory