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Foxp3tm4(EGFP/icre)Tch - Mouse-other
Recombinase Activity Detail
Allele Information
Allele:
Foxp3tm4(EGFP/icre)Tch
forkhead box P3; targeted mutation 4, Talal A Chatila 		Driver: Foxp3
Type: Targeted (Recombinase, Reporter)
Synonym: Foxp3deltaEGFPiCre
Molecular description: The targeting construct consisting of the IRES-EGFP-iCre sequence inserted immediately downstream of the Foxp3 translational stop codon and upstream of the endogenous polyadenylation signal and additional FRT flanked PGK-neo cassette inserted between exons 9-10 was used for homologous recombination in the ES cells. The PGK-neo cassette was removed by mating founder males with Flp-deleter female mice. Inserted Frt element inserted between exons 9 and 10 that created an aberrant 3 splice junction site, leading to a premature stop codon in the Foxp3 transcript.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Tissue Information
Mouse-other Other recombinase alleles with activity in Mouse-other tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory