About   Help   FAQ
Tg(Nkx2-5-tTA,tetO-EGFP/cre)1Smwu - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Nkx2-5-tTA,tetO-EGFP/cre)1Smwu
transgene insertion 1, Sean Wu 		Driver: Nkx2-5
Type: Transgenic (Inducible, Recombinase, Reporter)
Inducer: doxycycline/tetracycline
Synonym: Nkx2.5 enh-Cre
Molecular description: The transgene was designed with (from 5' to 3') with a mouse NK2 homeobox 5 locus (Nkx2-5) promoter/enhancer sequence (2.1 kbp enhancer fragment from the regulatory region ~9.5 kbp upstream of the translation start site and the 0.5 kbp base promoter sequence), a Tet-Off cassette, an enhanced green fluorescent protein/Cre recombinase fusion gene sequence (eGFP/Cre) and a G-CSF polyA sequence. The Tet-Off cassette contains a tetracycline-regulated transactivator sequence (tTA), 2x polyA sequence and tetracycline-responsive element (TRE with minimal cytomegalovirus promoter CMVmin).
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Images
Drag images to compare to others or to data in the table below. Drag corners to resize images for more detail. Reset Images
J:256545 Fig. 4
Recombinase Activity
Click heading to re-sort table.
Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory