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Lhx1 cDNA1 Probe Detail
Nucleotide
Probe/Clone
  • Name
    Lhx1 cDNA1
  • Sequence Type
    cDNA
  • ID
    MGI:20736
  • Region Covered
    encodes 5' untranslated sequence (0.89kb), coding region (1.22kb) and 3' untranslated sequence (0.08kb)
  • Child Clones
  • Vector Type
    Plasmid
  • Insert Site
    EcoRI
  • Insert Size
    2.2kb
Source
  • Species
    mouse, laboratory
  • Age
    embryonic day 8.5
  • Tissue
    embryo
Genes
Lhx1 LIM homeobox protein 1
Expression
  • Assay Results
    96
Sequences
Polymorphisms
J:16971 Barnes JD, et al., Dev Biol. 1994 Jan;161(1):168-78
Notes: A 1.2kb EcoRI/KpnI fragment encoding the first domain was used in Southern analysis.
Endonuclease Gene Allele Fragments Strains
DraI Lhx1 b 5.5kb C57BL/6J
s 8.0kb SPRET/EiJ
References
J:16971 Barnes JD, et al., Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. Dev Biol. 1994 Jan;161(1):168-78
J:30828 Ang SL, et al., A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development. 1996 Jan;122(1):243-52
J:40605 Miyamoto N, et al., Defects of urogenital development in mice lacking Emx2. Development. 1997 May;124(9):1653-64
J:46852 Yang X, et al., The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3667-72
J:53656 Perea-Gomez A, et al., HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo. Development. 1999 Oct;126(20):4499-511
J:57670 Mishina Y, et al., Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis. Dev Biol. 1999 Sep 15;213(2):314-26
J:60834 Kume T, et al., Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. Development. 2000 Apr;127(7):1387-95
J:68215 Xue Y, et al., Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK). Development. 2001 May;128(9):1559-72
J:77125 Norris DP, et al., The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo. Development. 2002 Jul;129(14):3455-68
J:86144 Miura S, et al., Whole-embryo culture of E5.5 mouse embryos: development to the gastrulation stage. Genesis. 2003 Sep;37(1):38-43
J:91443 Wilm B, et al., The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. Dev Biol. 2004 Jul 1;271(1):176-89
J:108109 Oxburgh L, et al., TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development. 2004 Sep;131(18):4593-605
J:124356 Bondareva AA, et al., Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome. Free Radic Biol Med. 2007 Sep 15;43(6):911-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory