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International Mouse Mutagenesis Consortium (IMMC)

The IMMC goals are described in Science 291:1251-1255, 2001 as:

1. Produce at least one heritable mutation, in either ES cells or mice, in every gene in the genome.
2. Identify every gene that affects key traits of biomedical interest.
3. Establish an infrastructure for preserving and distributing mutant cells and mice.
4. Enhance the informatics and database support for these functional studies.

Links to Mutagenesis Centers:

• Australian Phenomics Facility
  
• Baylor Mouse Mutagenesis for Development Defects
• Harwell Mutagenesis Programme
• Harvard's Mutation Mapping and Developmental Analysis Project
• The Jackson Laboratory Neuroscience Mutagenesis Facility
• The Jackson Laboratory Heart, Lung, Blood and Sleep Disorders Mutagenesis Program
• McLaughlin Institute Mouse Mutagenesis Program
• Northwestern University Center for Functional Genomics
• RIKEN Mouse Mutagenesis Program
• The Sloan-Kettering Mouse Project
• Tennessee Mouse Genome Consortium
• Toronto's Centre for Modeling Human Disease

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International Complex Traits Consortium (CTC)

The CTC focuses on exploring the complex interplay between gene variants, disease, and the environment.

See the The Complex Trait Consortium web site for current information.

Read the report of Complex Traits Workshop, January 29, 1998.

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International Gene Trap Consortium (IGTC)

The IGTC focuses on creating resources of embryonic stem cells with gene trap insertions in every or most genes in the mouse genome. A brief description of the gene trap consortium is available online.

The Gene Trap Consortium is also described in Nature Genetics 36: 543-544, 2004.

Links to Databases of Gene Trapped ES Cell Lines:

• BayGenomics
• German Gene Trap Consortium
• Embryonic Stem Cell Database
• Sanger Institute Gene Trap Resource (SIGTR)
• Soriano Lab Gene Trap Database
• Centre for Modeling Human Disease

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Animal Resources Links

• International Mouse Strain Resources (IMSR): global searchable catalog of mouse strain resources
• JAX Mice (The Jackson Laboratory): mouse product list, technical support, mice
• Induced Mutant Resource (IMR): genetically engineered mice, The Jackson Laboratory
• Mutant Mouse Regional Resource Centers (MMRRC): mouse strain and ordering information from NCRR's regional mutant mouse repositories
• Mammalian Genetics Unit (MGU): mouse stock list, mouse Embryo Bank, MRC,Harwell
• European Mouse Mutant Archive (EMMA): repository for transgenic mouse lines, Italy
• Oak Ridge National Laboratory (ORNL): mouse mutant stocks, Oak Ridge National Laboratory
• Neuromice.org: database and repository of mouse neurological mutants
• Charles River Laboratories, Inc.: mice, rats, guinea pigs, hamsters, gerbils, swine
• Taconic: mice, rats, transgenics
• Harlan Sprague Dawley, Inc.: rats, mice, other mammals, bedding, diets

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Data submission forms and nomenclature guides

Data submission forms

• Submit mutant, allele, and phenotype data
• Propose/reserve a new locus symbol

Nomenclature guides

• Mouse Gene, Allele, and Mutation Nomenclature Guidelines
• Rules for Nomenclature of Mouse and Rat Strains
• Laboratory Code Registry (ILAR): for strains, loci, transgenes, mutations

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