The laboratory mouse is the primary model organism for the study of human biology and disease. An inbred strain of mice represents a unique fixed genotype that can be accessed repeatedly as individual yet homogeneous experimental subjects with a predictable phenotype and defined allelic complement. Hundreds of inbred strains of mice have been described and new strains continue to be developed, taking advantage of the rich genetic diversity among the existing strains and the ease with which the mouse genome can be manipulated.
The genealogy chart of inbred strains graphically depicts the origins and relationships of inbred mouse strains.
Beck JA, Lloyd S, Hafezparast M, Lennon-Pierce M, Eppig JT, Festing MFW, Fisher EMC. 2000. Genealogies of mouse inbred strains. Nature Genetics 24: 23-25. J:59229 PubMed
The chart is available as a downloadable Portable Document Format (PDF) file (file size: 4398 Kbytes).
Accompanying the chart is a Key to the Chart of Strain Genealogies providing, for each strain on the Chart, location coordinates, a reference to its genealogy, and an indication whether it was extant when the chart was generated.
These files are available through the courtesy of Nature Genetics. In the future, the chart and its data will be incorporated into the Mouse Genome Database (MGD), where fuller historical tracking can be documented and the chart continuously updated and expanded.
Additional information on Inbred Strains is available at Strains, SNPs and Polymorphisms.
To submit additional information on the genealogy or genetics of inbred mouse strains, send email to firstname.lastname@example.org
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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