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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
MGI:99923
38 phenotypes from 3 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Kcnma1tm1Ruth/Kcnma1tm1Ruth
129-Kcnma1tm1Ruth
abnormal cochlear IHC afferent innervation pattern J:109217
abnormal cochlear inner hair cell physiology J:109217
abnormal cochlear nerve fiber response J:109217
abnormal distortion product otoacoustic emission J:109217
abnormal hearing electrophysiology J:109217
Kcnma1tm1Ruth/Kcnma1tm1Ruth
involves: 129/Sv * C57BL/6
abnormal digestive system physiology J:135743
abnormal eye blink conditioning behavior J:91427
abnormal feces composition J:135743
abnormal gait J:91427
abnormal motor capabilities/coordination/movement J:91427
abnormal muscle contractility J:148424
abnormal postnatal growth J:91427
abnormal urinary bladder physiology J:148424
ataxia J:91427
impaired ability to fire action potentials J:91427
impaired coordination J:91427
impaired swimming J:91427
increased blinking frequency J:91427
increased muscle relaxation J:148424
increased synaptic depression J:91427
increased systemic arterial blood pressure J:91427
increased urination frequency J:148424
short stride length J:91427
tremors J:91427
Kcnma1tm1Ruth/Kcnma1tm1Ruth
involves: 129X1/SvJ
absent distortion product otoacoustic emissions J:92443
cochlear outer hair cell degeneration J:92443, J:117764
Deiters cell degeneration J:92443
increased apoptosis J:92443
increased susceptibility to noise-induced hearing loss J:117764
sensorineural hearing loss J:92443
Kcnma1tm1Ruth/Kcnma1tm2.1Ruth
X/Tg(Myh11-cre/ERT2)1Soff
involves: 129/Sv * C57BL/6 * FVB/N
abnormal muscle contractility J:148424
abnormal urinary bladder physiology J:148424
increased urination frequency J:148424
Kcnma1tm1Rwa/Kcnma1tm1Rwa
FVB.129-Kcnma1tm1Rwa
abnormal cochlear inner hair cell physiology J:117811
abnormal gait J:92539
abnormal urinary bladder physiology J:92539
ataxia J:92539
decreased body weight J:92539
decreased litter size J:92539
decreased susceptibility to noise-induced hearing loss J:117811
impaired coordination J:92539
increased urination frequency J:92539
premature death J:92539
short stride length J:92539
unidirectional circling J:92539
urinary incontinence J:92539
Kcnma1tm1Rwa/Kcnma1tm1Rwa
involves: 129S1/Sv * 129X1/SvJ
abnormal action potential J:225860
abnormal channel response J:225860

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory