Adora1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Adora1
adenosine A1 receptor
MGI:99401

23 phenotypes from 4 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Adora1^{tm1b(KOMP)Wtsi}/Adora1^{tm1b(KOMP)Wtsi} B6N(Cg)-Adora1^{tm1b(KOMP)Wtsi}/J	increased exploration in new environment	J:211773
	increased lean body mass	J:211773
	increased mean corpuscular hemoglobin	J:211773
	increased vertical activity	J:211773
Adora1^tm1Bbf/Adora1^tm1Bbf B6.129P2-Adora1^tm1Bbf	allodynia	J:149872
Adora1^tm1Bbf/Adora1^tm1Bbf B6.129P2-Adora1^tm1Bbf	decreased thermal nociceptive threshold	J:149872
Adora1^tm1Bbf/Adora1^tm1Bbf involves: 129P2/OlaHsd * C57BL	abnormal body temperature homeostasis	J:70664
	abnormal CNS synaptic transmission	J:70664
	abnormal excitatory postsynaptic currents	J:70664
	abnormal excitatory postsynaptic potential	J:70664
	abnormal respiratory mechanics	J:70664
	normal cardiovascular system phenotype	J:70664
	decreased synaptic depression	J:70664
	decreased thermal nociceptive threshold	J:70664
	hyperalgesia	J:70664
	increased anxiety-related response	J:70664
Adora1^tm1Bbf/Adora1^tm1Bbf involves: 129P2/OlaHsd * C57BL/6	normal homeostasis/metabolism phenotype	J:99612
Adora1^tm1Jgsc/Adora1^tm1Jgsc involves: 129S1/Sv * 129X1/SvJ	abnormal response/metabolism to endogenous compounds	J:92598
Adora1^tm1Jgsc/Adora1^tm1Jgsc involves: 129S1/Sv * 129X1/SvJ * C57BL/6	increased circulating creatinine level	J:127544
	increased susceptibility to kidney reperfusion injury	J:127544
Adora1^tm1Jgsc/Adora1^tm1Jgsc involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	absent tubuloglomerular feedback response	J:71091
	normal cardiovascular system phenotype	J:71091
	normal homeostasis/metabolism phenotype	J:71091
	normal renal/urinary system phenotype	J:71091
Adora1^tm1Rgrn/Adora1^tm1Rgrn involves: 129S4/SvJae * C57BL/6	no abnormal phenotype detected	J:120655
Adora1^tm1Rgrn/Adora1^tm1Rgrn involves: 129S4/SvJae * C57BL/6	abnormal excitatory postsynaptic potential	J:120655
	abnormal nervous system electrophysiology	J:120655

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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