Wnt7b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Wnt7b
wingless-type MMTV integration site family, member 7B
MGI:98962

39 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Twist2^tm1(cre)Dor/Twist2⁺ Wnt7b^tm1Parr/Wnt7b^tm2Amc involves: 129S1/Sv * 129X1/SvJ	abnormal bone ossification	J:117333
	abnormal osteoblast differentiation	J:117333
	decreased width of hypertrophic chondrocyte zone	J:117333
Wnt7b^tm1.1Amc/Wnt7b^tm1.1Amc involves: 129X1/SvJ * C57BL/6 * CBA	decreased survivor rate	J:101493
	neonatal lethality, incomplete penetrance	J:101493
	persistence of hyaloid vascular system	J:101493
Wnt7b^tm1Eem/Wnt7b^tm1Eem either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal lung morphology	J:79395
	abnormal lung vasculature morphology	J:79395
	abnormal mesenchymal cell proliferation involved in lung development	J:79395
	decreased type I pneumocyte number	J:79395
	lung hemorrhage	J:79395
	neonatal lethality, complete penetrance	J:79395
	pulmonary hypoplasia	J:79395
	respiratory failure	J:79395
	thin lung-associated mesenchyme	J:79395
Wnt7b^tm1Parr/Wnt7b^tm1Parr involves: 129S1/Sv	abnormal chorioallantoic fusion	J:71583
	abnormal chorion morphology	J:71583
	abnormal placenta development	J:71583
	embryonic lethality, complete penetrance	J:71583
Wnt7b^tm2.1Amc/Wnt7b^tm2.1Amc involves: 129X1/SvJ	embryonic lethality, complete penetrance	J:134483
Wnt7b^tm2Amc/Wnt7b^tm2.1Amc Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129X1/SvJ * C57BL/6 * CBA	abnormal kidney cell proliferation	J:142685
	abnormal kidney collecting duct epithelium morphology	J:142685
	abnormal kidney medulla development	J:142685
	abnormal kidney morphology	J:142685
	abnormal lung development	J:134483
	abnormal right lung middle lobe morphology	J:134483
	abnormal tracheal cartilage morphology	J:134483
	absent kidney medulla	J:142685
	atelectasis	J:134483
	cyanosis	J:134483
	decreased kidney cell proliferation	J:142685
	decreased lung weight	J:134483
	decreased mesenchymal cell proliferation involved in lung development	J:134483
	hydroureter	J:142685
	increased kidney apoptosis	J:142685
	lung hemorrhage	J:134483
	neonatal lethality, complete penetrance	J:134483
	small lung	J:134483
	thin lung-associated mesenchyme	J:134483
	truncated loop of Henle	J:142685
Wnt7b^tm2Amc/Wnt7b^tm2.1Amc Tg(Hoxb7-cre)13Amc/0 involves: 129X1/SvJ * C57BL/6	abnormal kidney morphology	J:142685
	absent kidney medulla	J:142685
	decreased urine osmolality	J:142685
	kidney failure	J:142685
	postnatal lethality, complete penetrance	J:142685

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