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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnni3
troponin I, cardiac 3
MGI:98783
33 phenotypes from 7 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(Myh6-Tnni3*L184)#Rste/0
B6.Cg-Tg(Myh6-Tnni3*L184)#Rste 		abnormal myocardial fiber physiology J:161911
decreased heart weight J:161911
Tg(Myh6-Tnni3*R146G)121Rbns/0
Not Specified 		abnormal myocardial fiber morphology J:243628
abnormal myocardial fiber physiology J:243628
cardiac hypertrophy J:243628
cardiac interstitial fibrosis J:243628
decreased cardiac muscle relaxation J:243628
increased cardiac muscle contractility J:243628
increased response of heart to induced stress J:243628
Tg(Myh6-Tnni3*R146G)121Rbns/Tg(Myh6-Tnni3*R146G)121Rbns
Not Specified 		postnatal lethality J:243628
premature death J:243628
Tg(Myh6-Tnni3*R146G)133Rbns/0
Not Specified 		abnormal heart morphology J:243628
abnormal heart ventricle morphology J:243628
abnormal I band morphology J:243628
abnormal myocardial fiber mitochondrial morphology J:243628
abnormal myocardial fiber morphology J:243628
abnormal myocardial fiber physiology J:243628
abnormal sarcomere morphology J:243628
abnormal sarcoplasmic reticulum morphology J:243628
abnormal Z line morphology J:243628
cardiac hypertrophy J:243628
cardiac interstitial fibrosis J:243628
postnatal lethality, complete penetrance J:243628
Tg(Myh6-Tnni3*R193H)42Xhu/0
involves: C57BL/6 		cardiomyopathy J:119991
decreased cardiac muscle contractility J:119991
decreased cardiac muscle relaxation J:119991
dilated heart atrium J:119991
Tg(Myh6-Tnni3*R193H)594Jmme/0
involves: C57BL/6 * SJL 		abnormal heart echocardiography feature J:186721
abnormal myocardial fiber physiology J:186721
cardiomyopathy J:186721
decreased cardiac muscle relaxation J:186721
decreased heart weight J:186721
impaired exercise endurance J:186721
increased cardiac muscle contractility J:186721
increased left ventricle diastolic pressure J:186721
increased systemic arterial diastolic blood pressure J:186721
small heart J:186721
Tnni3tm1Jdp/Tnni3tm1Jdp
involves: 129S6/SvEvTac * C57BL/6 		abnormal cardiovascular system physiology J:180606
preweaning lethality, complete penetrance J:180606
Tnni3tm1Jww/Tnni3tm1Jww
Not Specified 		abnormal cardiovascular system physiology J:53628
abnormal lung vasculature morphology J:53628
abnormal myocardial fiber morphology J:53628
abnormal myocardium layer morphology J:53628
abnormal sarcomere morphology J:53628
congestive heart failure J:53628
lethargy J:53628
postnatal lethality, complete penetrance J:53628
respiratory distress J:53628
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory