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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tgfb3
transforming growth factor, beta 3
MGI:98727
35 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tgfb1tm1Jmu/Tgfb1tm1Jmu
Tgfb3tm1Doe/Tgfb3+
involves: 129 * BALB/c * C57BL/6J * Swiss Webster 		intracranial hemorrhage J:136106
postnatal lethality, incomplete penetrance J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu
Tgfb3tm1Doe/Tgfb3+
involves: 129 * C57BL/6J * ICR * Swiss Webster 		abnormal brain vasculature morphology J:136106
hydrocephaly J:136106
intracranial hemorrhage J:136106
postnatal lethality, incomplete penetrance J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu
Tgfb3tm1Doe/Tgfb3+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster 		absent vitelline blood vessels J:136106
embryonic lethality during organogenesis, incomplete penetrance J:136106
intracranial hemorrhage J:136106
postnatal lethality, incomplete penetrance J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu
Tgfb3tm1Doe/Tgfb3tm1Doe
involves: 129 * BALB/c * C57BL/6J * Swiss Webster 		intracranial hemorrhage J:136106
prenatal lethality, incomplete penetrance J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu
Tgfb3tm1Doe/Tgfb3tm1Doe
involves: 129 * C57BL/6J * ICR * Swiss Webster 		abnormal brain vasculature morphology J:136106
cleft secondary palate J:136106
enlarged brain ventricles J:136106
hydrocephaly J:136106
intracranial hemorrhage J:136106
normal mortality/aging J:136106
neonatal lethality, complete penetrance J:136106
normal respiratory system phenotype J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu
Tgfb3tm1Doe/Tgfb3tm1Doe
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster 		absent vitelline blood vessels J:136106
embryonic lethality during organogenesis, incomplete penetrance J:136106
intracranial hemorrhage J:136106
prenatal lethality, incomplete penetrance J:136106
Tgfb2tm1Doe/Tgfb2+
Tgfb3tm1Doe/Tgfb3+
involves: 129P2/OlaHsd 		abnormal small intestinal villus morphology J:76342
decreased enterocyte apoptosis J:76342
Tgfb2tm1Doe/Tgfb2+
Tgfb3tm1Doe/Tgfb3tm1Doe
involves: 129P2/OlaHsd 		normal limbs/digits/tail phenotype J:76541
normal vision/eye phenotype J:105113
Tgfb2tm1Doe/Tgfb2tm1Doe
Tgfb3tm1Doe/Tgfb3+
involves: 129P2/OlaHsd 		abnormal cartilage development J:76541
abnormal cornea morphology J:105113
abnormal eye posterior chamber morphology J:105113
abnormal interdigital cell death J:76541
abnormal lens epithelium morphology J:105113
abnormal retina inner nuclear layer morphology J:105113
abnormal retina neuronal layer morphology J:105113
decreased corneal stroma thickness J:105113
decreased retina apoptosis J:105113
interdigital webbing J:76541
Tgfb2tm1Doe/Tgfb2tm1Doe
Tgfb3tm1Doe/Tgfb3tm1Doe
involves: 129P2/OlaHsd 		abnormal cartilage development J:76541
abnormal chondrocyte morphology J:76541
abnormal cornea morphology J:105113
abnormal digit development J:76541
abnormal eye posterior chamber morphology J:105113
abnormal interdigital cell death J:76541
abnormal lens epithelium morphology J:105113
abnormal retina apoptosis J:105113
abnormal retina inner nuclear layer morphology J:105113
abnormal retina neuronal layer morphology J:105113
decreased cornea thickness J:105113
decreased corneal stroma thickness J:105113
interdigital webbing J:76541
Tgfb3tm2(Tgfb1)Vk/Tgfb3tm2(Tgfb1)Vk
involves: 129S1/Sv * 129X1/SvJ 		abnormal nasal septum morphology J:128938
abnormal palatal shelf fusion at midline J:128938
abnormal suckling behavior J:128938
cleft palate J:128938
postnatal lethality, complete penetrance J:128938
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory