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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tgfb3
transforming growth factor, beta 3
MGI:98727
38 phenotypes from 6 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tgfb3tm1(cre)Vk/Tgfb3tm1(cre)Vk
involves: 129S1/Sv * 129X1/SvJ 		cleft palate J:128938
Tgfb3tm1.1(KOMP)Vlcg/Tgfb3+
C57BL/6N-Tgfb3tm1.1(KOMP)Vlcg/Tcp 		abnormal testis morphology J:211773
enlarged lymph nodes J:211773
Tgfb3tm1.1(KOMP)Vlcg/Tgfb3tm1.1(KOMP)Vlcg
C57BL/6N-Tgfb3tm1.1(KOMP)Vlcg/Tcp 		preweaning lethality, complete penetrance J:211773
Tgfb3tm1Doe/Tgfb3+
involves: 129P2/OlaHsd 		abnormal small intestinal villus morphology J:76342
decreased enterocyte apoptosis J:76342
Tgfb3tm1Doe/Tgfb3tm1Doe
either: (involves: 129 * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CF-1) 		abnormal respiratory conducting tube morphology J:29901
absent gastric milk in neonates J:29901
anterior cleft palate J:29901
cleft palate J:29901
complete cleft palate J:29901
cyanosis J:29901
dehydration J:29901
neonatal lethality, complete penetrance J:29901
persistence of medial edge epithelium during palatal shelf fusion J:29901
respiratory distress J:29901
Tgfb3tm1Doe/Tgfb3tm1Doe
involves: 129 * C57BL/6J * ICR * Swiss Webster 		cleft palate J:136106
normal respiratory system phenotype J:136106
Tgfb3tm1Doe/Tgfb3tm1Doe
involves: 129P2/OlaHsd * C57BL/6 		decreased neuron apoptosis J:117465
loss of dopaminergic neurons J:117465
Tgfb3tm1Doe/Tgfb3tm1Doe
involves: 129P2/OlaHsd * C57BL/6J 		abnormal periderm development J:315539
abnormal secondary palate development J:315539
cleft palate J:315539
persistence of medial edge epithelium during palatal shelf fusion J:315539
Tgfb3tm1Jhg/Tgfb3tm1Jhg
either: (involves: 129S1/Sv * 129X1/SvJ * Black Swiss) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) 		abnormal lung development J:29902, J:111447
abnormal lung saccule morphology J:111447
abnormal lung vasculature morphology J:29902, J:111447
abnormal pulmonary alveolus morphology J:29902
abnormal pulmonary elastic fiber morphology J:111447
abnormal pulmonary interalveolar septum morphology J:29902
abnormal pulmonary vein morphology J:29902
abnormal suckling behavior J:29902
absent gastric milk in neonates J:29902
atelectasis J:29902
cleft secondary palate J:29902
cyanosis J:29902
decreased type II pneumocyte number J:29902, J:111447
dilated respiratory conducting tube J:29902
hemothorax J:29902
impaired lung alveolus development J:29902
lung hemorrhage J:29902
neonatal lethality, complete penetrance J:29902
persistence of medial edge epithelium during palatal shelf fusion J:29902
pulmonary hypoplasia J:29902
respiratory distress J:29902
thick lung-associated mesenchyme J:29902, J:111447
Tgfb3tm1Moaz/Tgfb3tm1.1Moaz
Tg(EIIa-cre)C5379Lmgd/0
involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * FVB/N 		abnormal suckling behavior J:181226
absent gastric milk in neonates J:181226
cleft palate J:181226
complete cleft palate J:181226
neonatal lethality, complete penetrance J:181226
respiratory distress J:181226
Tgfb3tm1Moaz/Tgfb3tm1Moaz
involves: 129S6/SvEvTac * Black Swiss * C57BL/6J 		no abnormal phenotype detected J:181226
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory