Abcb1a Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Abcb1a
ATP-binding cassette, sub-family B member 1A
MGI:97570

12 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Abcb1a^tm1Bor/Abcb1a^tm1Bor Abcb1b^tm1Bor/Abcb1b^tm1Bor FVBTac.129P2-Abcb1b^tm1Bor Abcb1a^tm1Bor	abnormal CD8 positive, alpha-beta intraepithelial T cell morphology	J:102640
	abnormal T cell physiology	J:102640
	abnormal xenobiotic pharmacokinetics	J:102640, J:107822
	decreased gamma-delta intraepithelial T cell number	J:102640
	increased double-positive T cell number	J:102640
	increased interferon-gamma secretion	J:102640
	increased interleukin-2 secretion	J:102640
Abcb1a^tm1Bor/Abcb1a^tm1Bor Abcb1b^tm1Bor/Abcb1b^tm1Bor involves: 129P2/OlaHsd * FVB	abnormal xenobiotic pharmacokinetics	J:39804
Abcb1a^tm1Bor/Abcb1a^tm1Bor Abcb1b^tm1Bor/Abcb1b^tm1Bor Abcc2^tm1Ahs/Abcc2^tm1Ahs FVB.129P2-Abcb1b^tm1Bor Abcb1a^tm1Bor Abcc2^tm1Ahs	abnormal xenobiotic pharmacokinetics	J:107822
Abcb1a^tm1Bor/Abcb1a^tm1Bor Abcb1b^tm1Bor/Abcb1b^tm1Bor Tg(Thy1-APPDutch)#Jckr/0 FVB.Cg-Abcb1b^tm1Bor Abcb1a^tm1Bor Tg(Thy1-APPDutch)#Jckr	amyloid beta deposits	J:178230
Abcb1a^tm1Bor/Abcb1a^tm1Bor Abcb1b^tm1Bor/Abcb1b^tm1Bor Tg(Thy1-APPSw,Thy1-PSEN1L166P)21Jckr/0 FVB.Cg-Abcb1b^tm1Bor Abcb1a^tm1Bor Tg(Thy1-APPSw,Thy1-PSEN1L166P)21Jckr	amyloid beta deposits	J:178230
Abcb1a^tm1Bor/Abcb1a^tm1Bor Npc1^m1N/Npc1^m1N involves: 129/Ola * BALB/c	abnormal maternal nurturing	J:76395
	abnormal motor capabilities/coordination/movement	J:76395
	increased liver cholesterol level	J:76395
	normal reproductive system phenotype	J:76395

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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