67 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pcsk1em2Irli/Pcsk1em2Irli C57BL/6J-Pcsk1em2Irli	abnormal intestinal goblet cell morphology	J:324309
	abnormal pancreas physiology	J:324309
	abnormal pancreatic islet morphology	J:324309
	abnormal pituitary gland physiology	J:324309
	decreased adrenocorticotropin level	J:324309
	decreased body size	J:324309
	decreased circulating glucose level	J:324309
	decreased enteroendocrine cell number	J:324309
	increased circulating insulin level	J:324309
	postnatal growth retardation	J:324309
	postnatal lethality, incomplete penetrance	J:324309
	premature death	J:324309
Pcsk1mpc242H/Pcsk1mpc242H involves: BALB/c * C3H/HeH * C57BL/6J	diarrhea	J:234901
	impaired glucose tolerance	J:234901
	insulin resistance	J:234901
	obese	J:234901
Pcsk1N222D/Pcsk1N222D C57BL/6-Pcsk1N222D	abnormal inguinal fat pad morphology	J:109531
	abnormal metabolism	J:109531
	decreased skeletal muscle mass	J:109531
	decreased testis weight	J:109531
	increased body weight	J:109531
	increased circulating leptin level	J:109531
	increased skeletal muscle mass	J:109531
	increased white adipose tissue amount	J:109531
	obese	J:109531
	polyphagia	J:109531
	reduced fertility	J:109531
Pcsk1tm1b(EUCOMM)Wtsi/Pcsk1+ C57BL/6N-Pcsk1tm1b(EUCOMM)Wtsi/Ics	abnormal freezing behavior	J:211773
	abnormal retina blood vessel morphology	J:211773
	abnormal retina vasculature morphology	J:211773
	abnormal vitreous body morphology	J:211773
	decreased locomotor activity	J:211773
	persistence of hyaloid vascular system	J:211773
Pcsk1tm1b(EUCOMM)Wtsi/Pcsk1tm1b(EUCOMM)Wtsi C57BL/6N-Pcsk1tm1b(EUCOMM)Wtsi/Ics	preweaning lethality, incomplete penetrance	J:211773
Pcsk1tm1Dfs/Pcsk1+ involves: 129 * C57BL/6J	abnormal glucose tolerance	J:78369
	decreased circulating insulin level	J:78369
	obese	J:78369
Pcsk1tm1Dfs/Pcsk1tm1Dfs involves: 129	abnormal hormone level	J:117652
Pcsk1tm1Dfs/Pcsk1tm1Dfs involves: 129 * C57BL/6J	abnormal peritoneal macrophage morphology	J:184882
	abnormal spleen marginal zone morphology	J:184882
	abnormal spleen white pulp morphology	J:184882
	abnormal T-helper 1 cell differentiation	J:184882
	chronic diarrhea	J:78369
	decreased adrenocorticotropin level	J:78369
	decreased body weight	J:78369
	decreased circulating glucagon level	J:78369
	decreased circulating growth hormone level	J:78369
	decreased circulating insulin level	J:78369
	decreased follicular dendritic cell number	J:184882
	decreased mean systemic arterial blood pressure	J:184882
	decreased NK T cell number	J:184882
	decreased T cell number	J:184882
	enlarged spleen	J:184882
	hypoglycemia	J:78369
	increased circulating interferon-gamma level	J:184882
	increased circulating interleukin-1 beta level	J:184882
	increased circulating interleukin-6 level	J:184882
	increased circulating interleukin-10 level	J:184882
	increased circulating interleukin-12 level	J:184882
	increased circulating tumor necrosis factor level	J:184882
	increased interleukin-1 beta secretion	J:184882
	increased lymphocyte cell number	J:184882
	increased susceptibility to endotoxin shock	J:184882
	increased susceptibility to xenobiotic induced morbidity/mortality	J:184882
	intermingled spleen red and white pulp	J:184882
	postnatal lethality, incomplete penetrance	J:78369
	prenatal lethality, incomplete penetrance	J:78369
Pcsk1tm1Mbi/Pcsk1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	normal homeostasis/metabolism phenotype	J:122555
	increased susceptibility to diet-induced obesity	J:122555
	slow postnatal weight gain	J:122555
	transmission ratio distortion	J:122555
Pcsk1tm1Mbi/Pcsk1tm1Mbi involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	embryonic lethality before implantation, complete penetrance	J:122555