Ntrk3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
MGI:97385

44 phenotypes from 7 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
\Ntrk3^tm1.1Tes/\Ntrk3^tm1.1Tes involves: 129S1/Sv	retina ganglion cell degeneration	J:171397
\Ntrk3^tm1.1Tes/\Ntrk3^tm1.1Tes involves: 129S1/Sv	normal vision/eye phenotype	J:171397
\Ntrk3^tm1Bbd/\Ntrk3^tm1Bbd involves: 129S2/SvPas * C57BL/6	abnormal cochlear IHC afferent innervation pattern	J:29245
	abnormal cochlear sensory epithelium morphology	J:29245
	abnormal lumbar dorsal root ganglion morphology	J:17195
	abnormal sensory neuron innervation pattern	J:17195
	athetotic walking movements	J:17195
	normal behavior/neurological phenotype	J:17195
	decreased body size	J:17195
	impaired coordination	J:17195
	impaired limb coordination	J:17195
	limb grasping	J:17195
	postnatal lethality	J:17195
	premature death	J:17195
	small cochlear ganglion	J:29245
	small vestibular ganglion	J:29245
\Ntrk3^tm1Ddg/\Ntrk3^tm1Ddg involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:99603
\Ntrk3^tm1Kln/\Ntrk3^tm1Kln involves: 129P2/OlaHsd * C57BL/6	abnormal cochlear nerve morphology	J:75365
	decreased sensory neuron number	J:75365
\Ntrk3^tm1Par/\Ntrk3^tm1Par involves: 129S1/Sv	decreased sensory neuron number	J:44286
\Ntrk3^tm1Par/\Ntrk3^tm1Par involves: 129S1/Sv	postnatal lethality, complete penetrance	J:44286
\Ntrk3^tm1Par/\Ntrk3^tm1Par involves: 129S1/Sv * C57BL/6	abnormal aortic valve morphology	J:45083
	abnormal cardiac outflow tract development	J:45083
	abnormal cranial ganglia morphology	J:45083
	abnormal heart septum morphology	J:45083
	abnormal heart valve morphology	J:45083
	abnormal mitral valve morphology	J:45083
	abnormal proprioceptive neuron morphology	J:45083
	abnormal pulmonary vein morphology	J:45083
	abnormal tricuspid valve morphology	J:45083
	abnormal truncus arteriosus septation	J:45083
	decreased sensory neuron number	J:45083
	dilated heart right ventricle	J:45083
	enlarged heart	J:45083
	globular heart	J:45083
	lung hemorrhage	J:45083
	ostium secundum atrial septal defect	J:45083
	postnatal lethality, complete penetrance	J:45083
	pulmonary valve hyperplasia	J:45083
	pulmonary valve hypertrophy	J:45083
	pulmonary valve stenosis	J:45083
	small cochlear ganglion	J:45083
	small L5 dorsal root ganglion	J:45083
	small nodose ganglion	J:45083
	small petrosal ganglion	J:45083
	small trigeminal ganglion	J:45083
	small vestibular ganglion	J:45083
	ventricular septal defect	J:45083
\Ntrk3^tm2.1Ddg/\Ntrk3^tm2.1Ddg involves: 129S6/SvEvTac * C57BL/6	neonatal lethality, complete penetrance	J:227979
\Ntrk3^{tm3.1(cre/ERT2)Ddg}/\Ntrk3^{tm3.1(cre/ERT2)Ddg} involves: 129S6/SvEvTac * C57BL/6	neonatal lethality, complete penetrance	J:227979

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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