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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Npr1
natriuretic peptide receptor 1
MGI:97371
39 phenotypes from 7 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Npr1tm1(Npr1)Unc/Npr1+
involves: 129P2/OlaHsd * C57BL/6
decreased systemic arterial blood pressure J:46175
Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
involves: 129P2/OlaHsd * C57BL/6
abnormal sex gland physiology J:58344
decreased systemic arterial blood pressure J:46175
increased circulating testosterone level J:58344
Npr1tm1.1Kkan/Npr1tm1.1Kkan
Tg(Tek-cre)1Ywa/0
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL
cardiac hypertrophy J:220676
increased metastatic potential J:220676
increased sensitivity to induced morbidity/mortality J:220676
increased systemic arterial blood pressure J:220676
Npr1tm1.1Rsha/Npr1+
involves: C57BL/6
cardiac hypertrophy J:201932
increased circulating aldosterone level J:201932
increased heart weight J:201932
increased mean systemic arterial blood pressure J:201932
increased systemic arterial systolic blood pressure J:201932
Npr1tm1.1Rsha/Npr1tm1.1Rsha
involves: C57BL/6
cardiac hypertrophy J:201932
increased circulating aldosterone level J:201932
increased heart weight J:201932
increased mean systemic arterial blood pressure J:201932
increased systemic arterial systolic blood pressure J:201932
Npr1tm1Gar/Npr1+
involves: 129S7/SvEvBrd * C57BL/6J
increased systemic arterial blood pressure J:30007
increased systemic arterial diastolic blood pressure J:30007
increased systemic arterial systolic blood pressure J:30007
salt-resistant hypertension J:30007
Npr1tm1Gar/Npr1tm1Gar
B6.129S7-Npr1tm1Gar
decreased myocardial infarction size J:70496
impaired neutrophil chemotaxis J:70496
Npr1tm1Gar/Npr1tm1Gar
involves: 129S7/SvEvBrd * C57BL/6J
abnormal systemic arterial blood pressure J:42893
abnormal vasodilation J:42893
hydrops fetalis J:30007
increased circulating atrial natriuretic factor J:42893
increased systemic arterial blood pressure J:30007
increased systemic arterial diastolic blood pressure J:30007
increased systemic arterial systolic blood pressure J:30007
normal mortality/aging J:30007
salt-resistant hypertension J:30007
Npr1tm1Kuhn/Npr1tm1Kuhn
Tg(Myh6-cre)2182Mds/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
abnormal cardiac muscle relaxation J:83298
abnormal myocardial fiber morphology J:83298
cardiac hypertrophy J:83298
cardiac interstitial fibrosis J:83298
congestive heart failure J:83298
decreased systemic arterial systolic blood pressure J:83298
hypotension J:83298
increased circulating atrial natriuretic factor J:83298
Npr1tm1Kuhn/Npr1tm1Kuhn
Tg(Tagln-cre)1Her/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
abnormal systemic arterial blood pressure J:76460
abnormal vasodilation J:76460
Npr1tm1Mae/Npr1+
B6.129P2-Npr1tm1Mae
congestive heart failure J:101857
Npr1tm1Mae/Npr1+
involves: 129P2/OlaHsd * C57BL/6
increased systemic arterial blood pressure J:46175
Npr1tm1Mae/Npr1tm1Mae
B6.129P2-Npr1tm1Mae
cardiac hypertrophy J:78579, J:101857
congestive heart failure J:101857
enlarged heart J:78579
hypertension J:78579
increased circulating atrial natriuretic factor J:78579
normal mortality/aging J:101857
Npr1tm1Mae/Npr1tm1Mae
involves: 129P2/OlaHsd * C57BL/6
abnormal myocardium layer morphology J:74420
abnormal pulmonary circulation J:74420
abnormal sex gland physiology J:58344
aortic dissection J:74420
cardiac hypertrophy J:74420
cardiac interstitial fibrosis J:74420
congestive heart failure J:74420
decreased circulating renin level J:74420
decreased circulating testosterone level J:58344
dilated heart left ventricle J:74420
dilated heart right ventricle J:74420
myocardium necrosis J:74420
premature death J:74420, J:101857
salt-resistant hypertension J:74420
Tg(Tek-Npr1)#Kkan/0
involves: C57BL/6
decreased metastatic potential J:220676
decreased sensitivity to induced morbidity/mortality J:220676

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory