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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Nedd4
neural precursor cell expressed, developmentally down-regulated 4
MGI:97297
31 phenotypes from 8 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Nedd4Gt(OST16211)Lex/Nedd4+
involves: 129S5/SvEvBrd * C57BL/6J
decreased body weight J:103485
Nedd4Gt(OST16211)Lex/Nedd4Gt(OST16211)Lex
involves: 129S5/SvEvBrd * C57BL/6J
neonatal lethality J:103485
Nedd4Gt(XA209)Byg/Nedd4Gt(XA209)Byg
involves: 129P2/OlaHsd
abnormal T cell activation J:143560
decreased B cell number J:143560
decreased IgG1 level J:143560
decreased IgG2b level J:143560
decreased IgG3 level J:143560
decreased interleukin-2 secretion J:143560
decreased T cell proliferation J:143560
increased CD4-positive, alpha beta T cell number J:143560
increased CD8-positive, alpha-beta T cell number J:143560
increased IgM level J:143560
increased T cell number J:143560
perinatal lethality, complete penetrance J:143560
Nedd4Gt(XB398)Byg/Nedd4Gt(XB398)Byg
involves: 129P2/OlaHsd
decreased B cell number J:143560
decreased IgG1 level J:143560
decreased IgG2b level J:143560
decreased IgG3 level J:143560
decreased interleukin-2 secretion J:143560
decreased T cell proliferation J:143560
increased CD4-positive, alpha beta T cell number J:143560
increased CD8-positive, alpha-beta T cell number J:143560
increased IgM level J:143560
increased T cell number J:143560
perinatal lethality, complete penetrance J:143560
Nedd4Gt(XB786)Byg/Nedd4Gt(XB786)Byg
involves: 129P2/OlaHsd
prenatal lethality, complete penetrance J:137202
Nedd4tm1Bros/Nedd4tm1Bros
Not Specified
prenatal lethality, complete penetrance J:137202
Nedd4tm2b(EUCOMM)Hmgu/Nedd4+
C57BL/6N-Nedd4tm2b(EUCOMM)Hmgu/H
decreased circulating creatinine level J:211773
impaired glucose tolerance J:211773
increased hemoglobin content J:211773
Nedd4tm2b(EUCOMM)Hmgu/Nedd4tm2b(EUCOMM)Hmgu
C57BL/6N-Nedd4tm2b(EUCOMM)Hmgu/H
preweaning lethality, complete penetrance J:211773
Nedd4tm2Bros/Nedd4tm2Bros
involves: C57BL/6N
abnormal dendrite morphology J:164745
abnormal excitatory postsynaptic currents J:164745
abnormal miniature excitatory postsynaptic currents J:164745
abnormal neuron morphology J:164745
abnormal synapse morphology J:164745
abnormal synaptic vesicle number J:164745
fetal growth retardation J:164745
hemorrhage J:164745
lethality throughout fetal growth and development, incomplete penetrance J:164745
normal nervous system phenotype J:164745
perinatal lethality, complete penetrance J:164745
Nedd4tm3.1Bros/Nedd4tm3.1Bros
Neurod6tm1(cre)Kan/Neurod6+
involves: 129 * C57BL/6 * C57BL/6N * SJL
abnormal cerebral hemisphere morphology J:164745
abnormal dendrite morphology J:164745
normal nervous system phenotype J:164745
thin cerebral cortex J:164745

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory