Mbl2 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mbl2
mannose-binding lectin (protein C) 2
MGI:96924

13 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Fcna^tm1Tefu/Fcna^tm1Tefu Mbl1^tm1Kata/Mbl1^tm1Kata Mbl2^tm1Kata/Mbl2^tm1Kata involves: 129S4/SvJae	normal immune system phenotype	J:177350
Mbl1^tm1Kata/Mbl1^tm1Kata Mbl2^tm1Kata/Mbl2^tm1Kata involves: 129 * C57BL/6	abnormal B cell number	J:97686
	abnormal circulating interleukin-6 level	J:98124
	abnormal circulating tumor necrosis factor level	J:98124
	decreased germinal center B cell number	J:97686
	decreased macrophage cell number	J:98124
	decreased monocyte cell number	J:98124
	impaired macrophage phagocytosis	J:97686, J:98124
	increased B-1 B cell number	J:97686
	increased susceptibility to bacterial infection	J:98124
Mbl1^tm1Kata/Mbl1^tm1Kata Mbl2^tm1Kata/Mbl2^tm1Kata involves: 129 * C57BL/6J	abnormal complement pathway	J:106351
	abnormal response to infection	J:106352
	decreased susceptibility to kidney reperfusion injury	J:106351
	increased susceptibility to bacterial infection	J:106353

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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