H2-I Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

H2-I
H2 I region, includes H2-Aa, Ab, Bl, Ea, Eb, Eb2, Ob, Pb
MGI:95903

16 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(Ins2-CD80)3B7Flv/0 Tg(Ins2-H2-Ea^d,Ins2-H2-Eb1^b)187-7Bri/0 involves: C57BL/6 * CBA/Ca * SJL	abnormal pancreatic islet morphology	J:93555
	dehydration	J:93555
	increased susceptibility to autoimmune diabetes	J:93555
	insulitis	J:93555
	premature death	J:93555
	weight loss	J:93555
Tg(Ins2-CD86)12B70Flv/0 Tg(Ins2-H2-Ea^d,Ins2-H2-Eb1^b)187-7Bri/0 involves: C57BL/6 * CBA/Ca * SJL	abnormal cytokine secretion	J:93555
	decreased pancreatic beta cell number	J:93555
	dehydration	J:93555
	increased circulating glucose level	J:93555
	increased susceptibility to autoimmune diabetes	J:93555
	insulitis	J:93555
	premature death	J:93555
	weight loss	J:93555
Tg(Ins2-H2-Ea^d,Ins2-H2-Eb1^b)187-7Bri/0 involves: C57BL/6 * SJL	decreased insulin secretion	J:127706
	decreased susceptibility to autoimmune diabetes	J:93555
	hyperglycemia	J:127706
	increased circulating glucose level	J:93555, J:127706
	increased circulating triglyceride level	J:127706
	ketoaciduria	J:127706
	polydipsia	J:127706
	polyuria	J:127706

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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