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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Flt1
FMS-like tyrosine kinase 1
MGI:95558
31 phenotypes from 9 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Flt1tm1.1Fong/Flt1tm1.1Fong
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * C57BL/6NCr * CD-1 		decreased body size J:202202
decreased myocardial infarct size J:202202
increased angiogenesis J:202202
increased endothelial cell proliferation J:202202
increased macrophage cell number J:202202
increased vascular permeability J:202202
Flt1tm1.1Vlcg/Flt1tm1.1Vlcg
involves: 129S6/SvEvTac * C57BL/6NTac 		no abnormal phenotype detected J:200671
Flt1tm1Eze/Flt1tm1Eze
Tg(Prrx1-cre)1Cjt/0
involves: C57BL/6J * SJL/J 		normal cardiovascular system phenotype J:147285
Flt1tm1Gne/Flt1tm1Gne
Not Specified 		corneal vascularization J:114973
Flt1tm1Jrt/Flt1+
involves: CD-1 		increased response of heart to induced stress J:101949
Flt1tm1Jrt/Flt1+
Not Specified 		abnormal blood circulation J:164891
abnormal blood vessel morphology J:164891
abnormal physiological neovascularization J:151369
increased angiogenesis J:164891
Flt1tm1Jrt/Flt1tm1.2Fong
involves: 129 * C57BL/6NCr * CD-1 		abnormal blood vessel morphology J:202202
Flt1tm1Jrt/Flt1tm1Jrt
either: (involves: 129/Sv) or (involves: CD-1) or (involves: ICR) 		abnormal embryo development J:54830
abnormal embryonic erythrocyte morphology J:54830
increased hemangioblast number J:54830
Flt1tm1Jrt/Flt1tm1Jrt
involves: 129S1/Sv * 129X1/SvJ 		abnormal dorsal aorta morphology J:26845
abnormal heart development J:26845
abnormal vascular development J:26845
abnormal visceral yolk sac blood island morphology J:26845
abnormal vitelline vasculature morphology J:26845
disorganized yolk sac vascular plexus J:26845
embryonic growth arrest J:26845
embryonic lethality during organogenesis, complete penetrance J:26845
Flt1tm1Msh/Flt1tm1Msh
involves: 129S4/SvJae * C57BL/6J 		normal cardiovascular system phenotype J:49507
corneal vascularization J:114973
impaired macrophage chemotaxis J:49507
normal reproductive system phenotype J:49507
Flt1tm1Msh/Flt1tm1Msh
involves: 129S4/SvJaeSor * C57BL/6 * FVB 		abnormal sensory capabilities/reflexes/nociception J:172783
neuron degeneration J:172783
Flt1tm2Msh/Flt1+
involves: 129S/SvEv * C57BL/6J 		abnormal embryo development J:95387
Flt1tm2Msh/Flt1tm2Msh
B6.129S-Flt1tm2Msh 		no abnormal phenotype detected J:95387
Flt1tm2Msh/Flt1tm2Msh
involves: 129S/SvEv * C57BL/6J 		abnormal dorsal aorta morphology J:95387
abnormal embryo turning J:95387
abnormal vascular development J:95387
abnormal vascular endothelial cell morphology J:95387
embryonic growth arrest J:95387
embryonic lethality during organogenesis, incomplete penetrance J:95387
Gt(ROSA)26Sortm1(Flt1,EGFP)Dlam/Gt(ROSA)26Sor+
Tg(Thy1-cre)1Dlam/0
involves: 129 * C57BL/6 * FVB 		abnormal sensory capabilities/reflexes/nociception J:172783
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory