Ctsl Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ctsl
cathepsin L
MGI:88564

17 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ctsb^tm1Jde/Ctsb^tm1Jde Ctsl^tm1Cptr/Ctsl^tm1Cptr involves: 129P2/OlaHsd * C57BL/6J	abnormal hippocampus pyramidal cell layer	J:77103
	abnormal motor coordination/balance	J:77103
	abnormal neuron apoptosis	J:77103
	decreased vertical activity	J:77103
	delayed hair appearance	J:77103
	gliosis	J:77103
	neuron degeneration	J:77103
	postnatal growth retardation	J:77103
	postnatal lethality, incomplete penetrance	J:77103
	Purkinje cell degeneration	J:77103
	thick epidermis	J:77103
	tremors	J:77103
Ctsk^tm1Psa/Ctsk^tm1Psa Ctsl^tm1Cptr/Ctsl^tm1Cptr involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J	abnormal thyroid follicle morphology	J:83877
	abnormal thyroid gland morphology	J:83877
	abnormal thyroid hormone level	J:83877
	decreased circulating thyroxine level	J:83877
	decreased thyroxine level	J:83877

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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