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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Col1a2
collagen, type I, alpha 2
MGI:88468
50 phenotypes from 4 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Col1a2oim/Col1a2+
B6C3Fe a/a-Col1a2oim/J 		abnormal compact bone morphology J:38013
decreased bone strength J:38013
Col1a2oim/Col1a2oim
B6C3Fe a/a-Col1a2oim/J 		abnormal compact bone lamellar structure J:38013
abnormal compact bone morphology J:38013
abnormal skin morphology J:124000
abnormal tendon morphology J:124000
normal cellular phenotype J:124000
decreased bone strength J:38013
Col1a2oim/Col1a2oim
involves: C3H/HeJ * C57BL/6JLe 		abnormal bone mineralization J:31692
abnormal caudal vertebrae morphology J:4348
abnormal compact bone lamellar structure J:4348
abnormal dermal layer morphology J:4348
abnormal forelimb morphology J:4348
abnormal gait J:4348
abnormal joint morphology J:4348
abnormal knee joint morphology J:4348
abnormal long bone morphology J:4348, J:31692
abnormal skin morphology J:4348
camptomelia J:4348
decreased body size J:4348
decreased bone mineral density J:4348
decreased bone trabecula number J:4348
decreased compact bone thickness J:4348, J:31692
decreased tendon stiffness J:41509
fragile skeleton J:4348, J:31692
hemorrhage J:4348
increased osteocyte number J:4348
kyphosis J:4348
scoliosis J:4348
Col1a2tm1.1Mcbr/Col1a2+
(A/J x B6.129-Col1a2tm1.1Mcbr)F1 		decreased body weight J:178743
decreased bone mineral content J:178743
decreased bone strength J:178743
decreased bone trabecula number J:178743
decreased bone volume J:178743
decreased compact bone area J:178743
decreased compact bone thickness J:178743
increased bone mineral density J:178743
increased volumetric bone mineral density J:178743
Col1a2tm1.1Mcbr/Col1a2+
(BALB/cByJ x B6.129-Col1a2tm1.1Mcbr)F1 		decreased body weight J:178743
decreased bone mineral content J:178743
decreased bone strength J:178743
decreased bone trabecula number J:178743
decreased bone volume J:178743
decreased compact bone area J:178743
decreased compact bone thickness J:178743
increased bone mineral density J:178743
increased volumetric bone mineral density J:178743
Col1a2tm1.1Mcbr/Col1a2+
(C3H/HeJ x B6.129-Col1a2tm1.1Mcbr)F1 		decreased body weight J:178743
decreased bone mineral content J:178743
decreased bone strength J:178743
decreased bone trabecula number J:178743
decreased bone volume J:178743
decreased compact bone area J:178743
decreased compact bone thickness J:178743
increased bone mineral density J:178743
increased volumetric bone mineral density J:178743
Col1a2tm1.1Mcbr/Col1a2+
(FVB/NJ x B6.129-Col1a2tm1.1Mcbr)F1 		decreased body weight J:178743
decreased bone mineral content J:178743
decreased bone strength J:178743
decreased bone trabecula number J:178743
decreased bone volume J:178743
increased bone mineral density J:178743
increased volumetric bone mineral density J:178743
Col1a2tm1.1Mcbr/Col1a2+
B6.129(Cg)-Col1a2tm1.1Mcbr 		decreased body weight J:121691
Col1a2tm1.1Mcbr/Col1a2tm1.1Mcbr
B6.129(Cg)-Col1a2tm1.1Mcbr 		perinatal lethality, complete penetrance J:178743
preweaning lethality, complete penetrance J:121691
Col1a2tm1b(EUCOMM)Wtsi/Col1a2tm1b(EUCOMM)Wtsi
C57BL/6N-Col1a2tm1b(EUCOMM)Wtsi/Bay 		abnormal femur morphology J:211773
abnormal tibia morphology J:211773
decreased blood urea nitrogen level J:211773
decreased total body fat amount J:211773
dilated heart left ventricle J:211773
increased bone mineral content J:211773
increased bone mineral density J:211773
increased circulating alkaline phosphatase level J:211773
increased heart weight J:211773
Col1a2tm1b(EUCOMM)Wtsi/Col1a2tm1b(EUCOMM)Wtsi
C57BL/6N-Col1a2tm1b(EUCOMM)Wtsi/BayMmucd 		decreased circulating amylase level J:211773
decreased grip strength J:211773
decreased lymphocyte cell number J:211773
enlarged heart J:211773
enlarged spleen J:211773
increased circulating alkaline phosphatase level J:211773
increased large unstained cell number J:211773
increased leukocyte cell number J:211773
increased neutrophil cell number J:211773
Col1a2tm1Mcbr/Col1a2tm1Mcbr
involves: 129/SvEv * C57BL/6 		no abnormal phenotype detected J:178743
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory