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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cd8b1
CD8 subunit beta 1
MGI:88347
16 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd8b1M1Btlr/Cd8b1+
C57BL/6J-Cd8b1M1Btlr 		decreased CD8-positive, naive alpha-beta T cell number J:255009
increased CD4-positive, alpha-beta T cell number J:255009
Cd8b1M1Btlr/Cd8b1M1Btlr
C57BL/6J-Cd8b1M1Btlr 		decreased CD8-positive, naive alpha-beta T cell number J:255009
enhanced humoral immune response J:255009
increased CD4-positive, alpha-beta T cell number J:255009
increased IgG level J:255009
Cd8b1m2Btlr/Cd8b1m2Btlr
C57BL/6J-Cd8b1m2Btlr 		abnormal B cell differentiation J:274761
abnormal CD8-positive, alpha-beta T cell differentiation J:274761
decreased CD8-positive, alpha-beta T cell number J:274761
decreased CD8-positive, naive alpha-beta T cell number J:274761
decreased T cell number J:274761
increased CD4-positive, alpha-beta T cell number J:274761
increased central memory CD8 positive, alpha-beta T cell number J:274761
increased effector memory CD8-positive, alpha-beta T cell number J:274761
Cd8b1tm1Litt/Cd8b1tm1Litt
involves: 129S4/SvJae * C57BL/6J 		abnormal cytotoxic T cell physiology J:112551
abnormal enzyme/coenzyme activity J:110916
abnormal T cell subpopulation ratio J:110916
decreased CD8-positive, alpha-beta T cell number J:110916, J:112551
decreased thymocyte number J:110916
Cd8b1tm1Wpfl/Cd8b1tm1Wpfl
involves: 129S2/SvPas 		abnormal CD8-positive, alpha beta T cell morphology J:19928
abnormal CD8-positive, alpha-beta T cell differentiation J:19928
abnormal T cell subpopulation ratio J:19928
decreased CD8-positive, alpha-beta T cell number J:19928
decreased thymocyte number J:19928
normal immune system phenotype J:19928
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory