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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cd247
CD247 antigen
MGI:88334
52 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd247m1Btlr/Cd247m1Btlr
C57BL/6J-Cd247m1Btlr 		abnormal CD4-positive, alpha-beta T cell physiology J:158794
Cd247tm1Lov/Cd247tm1Lov
B6.129S4-Cd247tm1Lov/J 		abnormal lateral geniculate nucleus morphology J:66246
abnormal long-term depression J:66246
enhanced long-term potentiation J:66246
enlarged lateral ventricles J:66246
reduced long-term depression J:66246
Cd247tm1Lov/Cd247tm1Lov
involves: 129S4/SvJae 		abnormal brain morphology J:66246
abnormal CNS synaptic transmission J:66246
abnormal excitatory postsynaptic potential J:66246
abnormal lateral geniculate nucleus morphology J:66246
abnormal single-positive T cell number J:14170
abnormal superior colliculus morphology J:66246
abnormal T-helper 1 cell morphology J:14170
abnormal T-helper 1 physiology J:46914
absent gamma-delta intraepithelial T cell J:46914
absent long-term depression J:66246
decreased CD4-positive, alpha-beta T cell number J:14170
decreased double-positive T cell number J:14170
decreased thymocyte number J:14170
enhanced long-term potentiation J:66246
Cd247tm1Lov/Cd247tm2.1Lov
involves: 129S4/SvJae 		normal immune system phenotype J:192915
Cd247tm1Mal/Cd247tm1Mal
either: C57BL/6-Cd247tm1Mal or (involves: BALB/c * C57BL/6) 		abnormal intraepithelial T cell morphology J:15272
abnormal T cell differentiation J:15272
decreased CD4-positive, alpha-beta T cell number J:15272
decreased CD8-positive, alpha-beta T cell number J:15272
decreased double-positive T cell number J:15272
decreased single-positive T cell number J:15272
decreased thymocyte number J:15272
increased double-negative T cell number J:15272
Cd247tm1Mal/Cd247tm1Mal
involves: C57BL/6 		abnormal double-negative T cell morphology J:110847, J:112990
abnormal T cell differentiation J:112990
abnormal T cell morphology J:110847
abnormal thymocyte activation J:110847
decreased double-positive T cell number J:110847
Cd247tm1Mhu/Cd247tm1Mhu
involves: 129S7/SvEvBrd * C57BL/6 		abnormal T cell differentiation J:15579
decreased CD4-positive, alpha-beta T cell number J:15579
decreased CD8-positive, alpha-beta T cell number J:15579
decreased double-positive T cell number J:15579
decreased splenocyte proliferation J:15579
decreased T cell proliferation J:15579
decreased thymocyte number J:15579
enlarged lymph nodes J:15579
enlarged spleen J:15579
enlarged thymus cortex J:15579
normal immune system phenotype J:15579
increased double-negative T cell number J:15579
small thymus J:15579
small thymus medulla J:15579
thymus hypoplasia J:15579
Cd247tm1Tks/Cd247tm1Tks
B6.129P2-Cd247tm1Tks 		abnormal NK cell morphology J:66403
abnormal NK cell physiology J:66403
decreased NK T cell number J:28282
increased interferon-gamma secretion J:66403
increased natural killer cell mediated cytotoxicity J:66403
Cd247tm1Tks/Cd247tm1Tks
involves: 129P2/OlaHsd * C57BL/6 		abnormal alpha-beta intraepithelial T cell morphology J:15271
abnormal T cell proliferation J:15271
decreased CD4-positive, alpha-beta T cell number J:15271
decreased CD8-positive, alpha-beta T cell number J:15271
decreased double-positive T cell number J:15271
decreased single-positive T cell number J:15271
decreased thymocyte number J:15271
small thymus medulla J:15271
Cd247tm2.1Lov/Cd247tm2.1Lov
B6.Cg-Cd247tm2.1Lov 		increased susceptibility to experimental autoimmune encephalomyelitis J:192915
Cd247tm2.1Lov/Cd247tm2.1Lov
Not Specified 		abnormal bone marrow cell physiology J:192915
abnormal gamma-delta T cell differentiation J:192915
abnormal NK T cell morphology J:192915
abnormal regulatory T cell physiology J:192915
abnormal T cell differentiation J:192915
abnormal T cell physiology J:192915
abnormal T-helper 1 cell differentiation J:192915
decreased CD4-positive, alpha-beta T cell number J:192915
decreased CD8-positive, alpha-beta T cell number J:192915
decreased thymocyte apoptosis J:192915
decreased thymocyte number J:192915
normal immune system phenotype J:192915
increased regulatory T cell number J:192915
Cd247tm2Lov/Cd247tm2Lov
Not Specified 		no abnormal phenotype detected J:192915
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory