Bglap Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bglap
bone gamma carboxyglutamate protein
MGI:88156

38 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Bglap/Bglap2^tm1Kry/Bglap/Bglap2^tm1Kry involves: 129S7/SvEvBrd	abnormal fat cell morphology	J:126780
	abnormal glucose homeostasis	J:126780
	abnormal pancreatic islet morphology	J:126780
	abnormal seminiferous tubule epithelium morphology	J:170888
	abnormal spermatid morphology	J:170888
	abnormal spermatocyte morphology	J:170888
	decreased adipocyte glucose uptake	J:126780
	decreased circulating insulin level	J:126780
	decreased circulating testosterone level	J:170888
	decreased energy expenditure	J:126780
	decreased epididymis weight	J:170888
	decreased insulin secretion	J:126780
	decreased Leydig cell number	J:170888
	decreased pancreatic beta cell mass	J:126780
	decreased pancreatic beta cell proliferation	J:126780
	decreased pancreatic islet number	J:126780
	decreased seminal vesicle weight	J:170888
	decreased testis weight	J:170888
	impaired glucose tolerance	J:126780
	increased circulating estradiol level	J:170888
	increased circulating glucose level	J:126780
	increased circulating luteinizing hormone level	J:170888
	increased circulating triglyceride level	J:126780
	increased total body fat amount	J:126780
	insulin resistance	J:126780
	oligozoospermia	J:170888
	normal reproductive system phenotype	J:170888
	small pancreatic islets	J:126780
	small testis	J:170888
Bglap/Bglap2^tm1Kry/Bglap/Bglap2^tm1Kry involves: 129S7/SvEvBrd * C57BL/6	abnormal bone remodeling	J:34440
	abnormal bone structure	J:34440
	abnormal long bone diaphysis morphology	J:34440
	abnormal skeleton development	J:34440
	increased bone mass	J:34440
	increased bone strength	J:34440
	increased compact bone thickness	J:34440
	increased osteoclast cell number	J:34440
	increased trabecular bone thickness	J:34440
Bglap/Bglap2^tm3.1Kry/Bglap/Bglap2^tm3.1Kry Tg(Col1a1-cre)1Kry/0 involves: FVB	decreased circulating testosterone level	J:170888
	decreased epididymis weight	J:170888
	decreased seminal vesicle weight	J:170888
	decreased testis weight	J:170888
	oligozoospermia	J:170888
	small testis	J:170888
Bglap/Bglap2^tm3.1Kry/Bglap/Bglap2^tm3.1Kry Tg(Cyp17a1-icre)AJako/0 involves: C57BL/6 * SJL	normal reproductive system phenotype	J:170888

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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