51 phenotypes from 5 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chrnb2tm1.1Cont/Chrnb2+ B6.129-Chrnb2tm1.1Cont	abnormal behavioral response to nicotine	J:228269
	decreased anxiety-related response	J:228269
	hyperactivity	J:228269
	increased susceptibility to induction of seizure by inducing agent	J:228269
Chrnb2tm1.1Cont/Chrnb2tm1.1Cont B6.129-Chrnb2tm1.1Cont	abnormal associative learning	J:228269
	abnormal behavior	J:228269
	abnormal behavioral response to nicotine	J:228269
	abnormal habituation to a new environment	J:228269
	decreased anxiety-related response	J:228269
	enhanced coordination	J:228269
	fragmentation of sleep/wake states	J:228269
	increased locomotor activity	J:228269
	increased susceptibility to induction of seizure by inducing agent	J:228269
	premature death	J:228269
Chrnb2tm1b(EUCOMM)Hmgu/Chrnb2+ C57BL/6N-Chrnb2tm1b(EUCOMM)Hmgu/H	increased circulating aspartate transaminase level	J:211773
Chrnb2tm1b(EUCOMM)Hmgu/Chrnb2tm1b(EUCOMM)Hmgu C57BL/6N-Chrnb2tm1b(EUCOMM)Hmgu/H	abnormal epididymis morphology	J:211773
	enlarged heart	J:211773
	increased total body fat amount	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Chrnb2tm1Jpc/Chrnb2tm1Jpc B6.129P2-Chrnb2tm1Jpc	abnormal brain morphology	J:77377
	abnormal lateral geniculate nucleus morphology	J:77377
	abnormal nervous system electrophysiology	J:109772
	abnormal nicotine-mediated receptor currents	J:54505
	abnormal superior colliculus morphology	J:77377
	decreased B cell number	J:112766
	decreased chemically-elicited antinociception	J:54505
	decreased visual acuity	J:77377
Chrnb2tm1Jpc/Chrnb2tm1Jpc involves: 129P2/OlaHsd	abnormal behavior	J:99880
	abnormal eye electrophysiology	J:139123
	abnormal lateral geniculate nucleus morphology	J:139123
	abnormal pulmonary ventilation	J:102005
	abnormal response to new environment	J:99880
	abnormal response to novelty	J:99880
	abnormal social investigation	J:99880
	abnormal tidal volume	J:102005
	apnea	J:102005
	decreased susceptibility to injury	J:102005
	enhanced spatial learning	J:99880
	increased pulmonary ventilation	J:102005
	increased tidal volume	J:102005
	normal respiratory system phenotype	J:102005
	normal vision/eye phenotype	J:139123
Chrnb2tm1Jpc/Chrnb2tm1Jpc involves: 129P2/OlaHsd * C57BL/6	abnormal immune system physiology	J:103908
	abnormal immunoglobulin level	J:103908
	decreased B cell number	J:103908
	decreased immunoglobulin level	J:103908
	normal immune system phenotype	J:103908
	increased B cell proliferation	J:103908
	increased IgG level	J:103908
Chrnb2tm1Jpc/Chrnb2tm1Jpc involves: 129P2/OlaHsd * C57BL/6 * DBA/2	abnormal brain morphology	J:23256
	abnormal nicotine-mediated receptor currents	J:23256
	normal behavior/neurological phenotype	J:23256
	normal homeostasis/metabolism phenotype	J:23256
	impaired passive avoidance behavior	J:23256
Chrnb2tm1Jpc/Chrnb2tm1Jpc involves: 129P2/OlaHsd * C57BL/6J	decreased erythroblast number	J:140280
	myeloid hyperplasia	J:140280
Chrnb2tm1Mdb/Chrnb2tm1Mdb involves: 129S7/SvEvBrd	abnormal eye electrophysiology	J:139123
	abnormal lateral geniculate nucleus morphology	J:139123
	normal vision/eye phenotype	J:139123
Chrnb2tm1Mdb/Chrnb2tm1Mdb involves: 129S7/SvEvBrd * C57BL/6J	no abnormal phenotype detected	J:73590
Tg(Prnp-tTA)F959Sbp/0 Tg(tetO-Chrnb2*V287L)H3Gica/0 involves: 129S7/SvEvBrd * FVB	abnormal brain wave pattern	J:145855
	seizures	J:145855