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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
MGI:87891
49 phenotypes from 5 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Chrnb2tm1.1Cont/Chrnb2+
B6.129-Chrnb2tm1.1Cont
abnormal behavioral response to nicotine J:228269
decreased anxiety-related response J:228269
hyperactivity J:228269
increased susceptibility to induction of seizure by inducing agent J:228269
Chrnb2tm1.1Cont/Chrnb2tm1.1Cont
B6.129-Chrnb2tm1.1Cont
abnormal associative learning J:228269
abnormal behavior J:228269
abnormal behavioral response to nicotine J:228269
abnormal habituation to a new environment J:228269
decreased anxiety-related response J:228269
enhanced coordination J:228269
fragmentation of sleep/wake states J:228269
hyperactivity J:228269
increased susceptibility to induction of seizure by inducing agent J:228269
premature death J:228269
Chrnb2tm1b(EUCOMM)Hmgu/Chrnb2+
C57BL/6N-Chrnb2tm1b(EUCOMM)Hmgu/H
persistence of hyaloid vascular system J:211773
Chrnb2tm1b(EUCOMM)Hmgu/Chrnb2tm1b(EUCOMM)Hmgu
C57BL/6N-Chrnb2tm1b(EUCOMM)Hmgu/H
abnormal epididymis morphology J:211773
enlarged heart J:211773
preweaning lethality, incomplete penetrance J:211773
Chrnb2tm1Jpc/Chrnb2tm1Jpc
B6.129P2-Chrnb2tm1Jpc
abnormal brain morphology J:77377
abnormal lateral geniculate nucleus morphology J:77377
abnormal nervous system electrophysiology J:109772
abnormal nicotine-mediated receptor currents J:54505
abnormal superior colliculus morphology J:77377
decreased B cell number J:112766
decreased chemically-elicited antinociception J:54505
decreased visual acuity J:77377
Chrnb2tm1Jpc/Chrnb2tm1Jpc
involves: 129P2/OlaHsd
abnormal behavior J:99880
abnormal eye electrophysiology J:139123
abnormal lateral geniculate nucleus morphology J:139123
abnormal pulmonary ventilation J:102005
abnormal response to new environment J:99880
abnormal response to novelty J:99880
abnormal social investigation J:99880
abnormal tidal volume J:102005
apnea J:102005
decreased susceptibility to injury J:102005
enhanced spatial learning J:99880
increased pulmonary ventilation J:102005
increased tidal volume J:102005
normal respiratory system phenotype J:102005
normal vision/eye phenotype J:139123
Chrnb2tm1Jpc/Chrnb2tm1Jpc
involves: 129P2/OlaHsd * C57BL/6
abnormal immune system physiology J:103908
abnormal immunoglobulin level J:103908
decreased B cell number J:103908
decreased immunoglobulin level J:103908
normal immune system phenotype J:103908
increased B cell proliferation J:103908
increased IgG level J:103908
Chrnb2tm1Jpc/Chrnb2tm1Jpc
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
abnormal brain morphology J:23256
abnormal nicotine-mediated receptor currents J:23256
normal behavior/neurological phenotype J:23256
normal homeostasis/metabolism phenotype J:23256
impaired passive avoidance behavior J:23256
Chrnb2tm1Jpc/Chrnb2tm1Jpc
involves: 129P2/OlaHsd * C57BL/6J
decreased erythroblast number J:140280
myeloid hyperplasia J:140280
Chrnb2tm1Mdb/Chrnb2tm1Mdb
involves: 129S7/SvEvBrd
abnormal eye electrophysiology J:139123
abnormal lateral geniculate nucleus morphology J:139123
normal vision/eye phenotype J:139123
Chrnb2tm1Mdb/Chrnb2tm1Mdb
involves: 129S7/SvEvBrd * C57BL/6J
no abnormal phenotype detected J:73590
Tg(Prnp-tTA)F959Sbp/0
Tg(tetO-Chrnb2*V287L)H3Gica/0
involves: 129S7/SvEvBrd * FVB
abnormal brain wave pattern J:145855
seizures J:145855

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory