Nlrp1a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nlrp1a
NLR family, pyrin domain containing 1A
MGI:2684861

34 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nlrp1a^em1(IMPC)Mbp/Nlrp1a^em1(IMPC)Mbp C57BL/6N-Nlrp1a^em1(IMPC)Mbp/MbpMmucd	abnormal eye morphology	J:211773
	abnormal heart morphology	J:211773
	enlarged heart	J:211773
	microphthalmia	J:211773
Nlrp1a^m1Btlr/Nlrp1a^m1Btlr C57BL/6J-Nlrp1a^m1Btlr	decreased B cell number	J:265173
	decreased B-1 B cell number	J:265173
	decreased B-1b cell number	J:265173
	decreased B-2 B cell number	J:265173
	decreased body weight	J:265173
	decreased CD8-positive, alpha-beta T cell number	J:265173
	decreased central memory CD8 positive, alpha-beta T cell number	J:265173
	decreased NK cell number	J:265173
	decreased single-positive T cell number	J:265173
	decreased T cell number	J:265173
	increased effector memory CD8-positive, alpha-beta T cell number	J:265173
	increased IgE level	J:265173
	increased macrophage apoptosis	J:265173
	increased tumor necrosis factor secretion	J:265173
Nlrp1a^m2Btlr/Nlrp1a^m2Btlr C57BL/6J-Nlrp1a^m2Btlr	decreased B cell number	J:265174
	decreased interleukin-1 beta secretion	J:265174
	decreased NK cell number	J:265174
	hypoglycemia	J:265174
	increased dendritic cell number	J:265174
	increased macrophage apoptosis	J:265174
	increased neutrophil cell number	J:265174
Nlrp1a^Neut1/Nlrp1a⁺ C.B6-Nlrp1a^Neut1	increased inflammatory response	J:191055
	liver inflammation	J:191055
	lung inflammation	J:191055
	meningitis	J:191055
	myocarditis	J:191055
	pancreas inflammation	J:191055
	normal reproductive system phenotype	J:191055
Nlrp1a^Neut1/Nlrp1a^Neut1 C.B6-Nlrp1a^Neut1	decreased lymphocyte cell number	J:191055
	decreased macrophage cell number	J:191055
	enlarged spleen	J:191055
	increased inflammatory response	J:191055
	increased macrophage cytokine production	J:191055
	increased neutrophil cell number	J:191055
	liver inflammation	J:191055
	lung inflammation	J:191055
	meningitis	J:191055
	myocarditis	J:191055
	pancreas inflammation	J:191055
	premature death	J:191055
	normal reproductive system phenotype	J:191055

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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