About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Spns2
SPNS lysolipid transporter 2, sphingosine-1-phosphate
MGI:2384936
74 phenotypes from 6 alleles in 8 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Spns2tm1.1Nmoc/Spns2tm1.1Nmoc
Tg(Tek-cre)1Ywa/0
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL 		abnormal B cell physiology J:184558
abnormal effector T cell morphology J:184558
abnormal T cell physiology J:184558
decreased CD4-positive, alpha-beta T cell number J:184558
decreased CD8-positive, alpha-beta T cell number J:184558
decreased mature B cell number J:184558
increased CD4-positive, alpha-beta T cell number J:184558
increased CD8-positive, alpha-beta T cell number J:184558
normal vision/eye phenotype J:184558
Spns2tm1.2Nmoc/Spns2tm1.2Nmoc
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal B cell physiology J:184558
abnormal T cell physiology J:184558
decreased B-1 B cell number J:184558
decreased CD4-positive, alpha-beta T cell number J:184558
decreased CD8-positive, alpha-beta T cell number J:184558
decreased follicular B cell number J:184558
decreased immature B cell number J:184558
decreased leukocyte cell number J:184558
decreased mature B cell number J:184558
decreased transitional stage T1 B cell number J:184558
increased CD4-positive, alpha-beta T cell number J:184558
increased CD8-positive, alpha-beta T cell number J:184558
increased single-positive T cell number J:184558
symblepharon J:184558
Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi 		abnormal behavior J:175295
abnormal cornea morphology J:165965
abnormal eye morphology J:165965
abnormal eye pigmentation J:165965
abnormal eye size J:165965
abnormal eyelid aperture J:165965
abnormal iris morphology J:165965
abnormal rib morphology J:165965
absent pinna reflex J:165965
corneal opacity J:165965
corneal vascularization J:165965
decreased leukocyte cell number J:165965
decreased lumbar vertebrae number J:165965
excessive tearing J:165965
increased bone mineral density J:165965
increased sacral vertebrae number J:165965
Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
involves: C57BL/6 * C57BL/6N 		abnormal auditory brainstem response J:213427
abnormal ciliary body morphology J:213427
abnormal cornea morphology J:213427
abnormal corneal stroma morphology J:213427
abnormal eye pigmentation J:188933, J:213427
abnormal humoral immune response J:188933
abnormal iridocorneal angle J:213427
abnormal iris morphology J:213427
abnormal pupil morphology J:213427
abnormal retina morphology J:213427
absent pinna reflex J:213427
cataract J:213427
corneal opacity J:213427
corneal vascularization J:213427
decreased B cell number J:188933, J:213427
decreased B-1 B cell number J:188933
decreased CD4-positive, alpha-beta T cell number J:188933, J:213427
decreased CD8-positive, alpha-beta T cell number J:188933, J:213427
decreased circulating glucose level J:213427
decreased follicular B cell number J:188933
decreased IgG1 level J:188933
decreased IgG level J:188933
decreased leukocyte cell number J:188933, J:213427
decreased mature B cell number J:213427
decreased T cell number J:213427
eye opacity J:188933, J:213427
eyelids fail to open J:213427
normal immune system phenotype J:188933
increased bone mineral content J:213427
increased bone strength J:213427
increased CD4-positive, alpha-beta T cell number J:188933
increased CD8-positive, alpha-beta T cell number J:188933
increased circulating bilirubin level J:213427
increased granulocyte number J:213427
increased incidence of corneal inflammation J:213427
increased monocyte cell number J:213427
increased NK cell number J:213427
increased NK T cell number J:213427
increased susceptibility to bacterial infection J:213427
microphthalmia J:213427
narrow eye opening J:213427
small lens J:213427
Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
B6Brd;B6Dnk;B6N-Tyrc-Brd Spns2tm1b(KOMP)Wtsi/WtsiH 		abnormal cornea morphology J:211773
abnormal iris morphology J:211773
absent pinna reflex J:211773
corneal opacity J:211773
corneal vascularization J:211773
decreased bone mineral content J:211773
decreased leukocyte cell number J:211773
increased mean corpuscular hemoglobin J:211773
narrow eye opening J:211773
trunk curl J:211773
Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N 		decreased B cell number J:188933
decreased CD4-positive, alpha-beta T cell number J:188933
decreased CD8-positive, alpha-beta T cell number J:188933
increased CD4-positive, alpha-beta T cell number J:188933
increased CD8-positive, alpha-beta T cell number J:188933
Spns2tm1c(KOMP)Wtsi/Spns2tm1c(KOMP)Wtsi
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N 		normal immune system phenotype J:188933
Spns2tm1Tni/Spns2tm1Tni
B6.Cg-Spns2tm1Tni 		abnormal leukocyte cell number J:225108
abnormal mature B cell number J:225108
abnormal thymus morphology J:225108
decreased body weight J:225108
decreased leukocyte cell number J:225108
decreased lymphocyte cell number J:225108
decreased monocyte cell number J:225108
decreased single-positive T cell number J:225108
decreased sphingosine level J:225108
decreased survivor rate J:225108
decreased thymocyte number J:225108
eyelids open at birth J:225108
normal growth/size/body region phenotype J:225108
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory