Map4k3 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Map4k3
mitogen-activated protein kinase kinase kinase kinase 3
MGI:2154405

17 phenotypes from 1 allele in 1 genetic background

Allelic Composition Genetic Background	Annotated Term	Reference
Map4k3^{Gt(RRO270)Byg}/Map4k3^{Gt(RRO270)Byg} involves: 129P2/OlaHsd	abnormal interleukin secretion	J:177642
	abnormal T-helper 1 cell differentiation	J:177642
	abnormal T-helper 2 cell differentiation	J:177642
	abnormal T-helper 17 cell differentiation	J:177642
	decreased IgG1 level	J:177642
	decreased IgG2a level	J:177642
	decreased IgG2b level	J:177642
	decreased IgG3 level	J:177642
	decreased IgM level	J:177642
	decreased immunoglobulin level	J:177642
	decreased interferon-gamma secretion	J:177642
	decreased interleukin-2 secretion	J:177642
	decreased interleukin-4 secretion	J:177642
	decreased interleukin-17 secretion	J:177642
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:177642
	decreased T cell proliferation	J:177642
	normal immune system phenotype	J:177642

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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